DegronMD

Uniprot ID: Q7Z591

Source protein: Microtubule organization protein AKNA

Source gene: AKNA

Class: DEG_SCF_TRCP1_1

Location: 923:929

E3 ligase: BTRC

DEGRON score: 0.9984

ASA_SCORE: 75.8143

COIL: 0.9399

CONS_SCORE: 0.769

DSS_SCORE: 0.6325

HELIX: 0.0403

FCONS_SCORE: 1.5015

RIG_SCORE: 0.6424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A918V	TCGA-55-8089	LUAD	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1944
p.A918V	TCGA-AX-A2HC	UCEC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1944
p.A918V	SIDM00989	Bladder Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1944
p.A918V	BFTC-905	urinary_tract	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	0.1944
p.P920T	TCGA-BF-A1Q0	SKCM	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.25
p.S935L	TCGA-GU-AATO	BLCA	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1667
p.E914K	SIDM00255	Neuroblastoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.0833
p.E914K	NB17	autonomic_ganglia	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	0.0833
p.A935T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	0.1667
p.R932Q	KMH-2	thyroid	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	0.25
p.R932Q	JHOS-4	ovary	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z591	Microtubule organization protein AKNA	DEG_SCF_TRCP1_1	923:929	DSGFVGS	BTRC	0.9984	More...
Q9HBE5	Interleukin-21 receptor	DEG_SCF_TRCP1_1	491:497	DSGFVGS	BTRC	0.7908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons