DegronMD

Uniprot ID: Q9HBE5

Source protein: Interleukin-21 receptor

Source gene: IL21R

Class: DEG_SCF_TRCP1_1

Location: 491:497

E3 ligase: BTRC

DEGRON score: 0.7908

ASA_SCORE: 48.9714

COIL: 0.803

CONS_SCORE: 0.8

DSS_SCORE: 0.4529

HELIX: 0.0909

FCONS_SCORE: 1.2444

RIG_SCORE: 0.6957

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L485Q	TCGA-56-8308	LUSC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1667
p.L485Q	DO219140	LUSC	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.1667
p.D491G	TCGA-98-8021	LUSC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.7198
p.D491G	DO27468	LUSC	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.7198
p.C505R	TCGA-AJ-A3OJ	UCEC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1111
p.C505R	DO42753	UCEC	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.1111
p.G496V	TCGA-BP-4801	KIRC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.6421
p.G496V	DO18066	KIRC	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.6421
p.S500R	TCGA-CQ-5332	HNSC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.25
p.S500R	DO14518	HNSC	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.25
p.P481S	TCGA-EE-A2ML	SKCM	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.0556
p.P481S	DO222429	MELA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.0556
p.P481S	DO37408	SKCM	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.0556
p.D488N	TCGA-EE-A3AG	SKCM	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.25
p.D488N	DO37471	SKCM	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.25
p.A483V	TCGA-GN-A4U3	SKCM	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1111
p.A483V	DO50970	LICA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.1111
p.A483V	DO219484	SKCM	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.1111
p.G484D	TCGA-IB-7651	PAAD	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484D	DO46657	PAAD	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.D498Y	DO228976	LICA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.3056
p.V503L	DO228971	LICA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.1667
p.G493V	DO229029	LICA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.7532
p.V495L	DO229035	LICA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.5654
p.D506Y	DO229041	LICA	ICGC	DSGFVGS	DEG_SCF_TRCP1_1	0.0833
p.G484S	SIDM00967	Ovarian Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00087	Plasma Cell Myeloma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM01039	Other Solid Cancers	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00694	Other Solid Cancers	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00879	Breast Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00875	Breast Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00930	Osteosarcoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00068	Colorectal Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM01140	Ovarian Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00808	Burkitt's Lymphoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM00628	Breast Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM01664	Prostate Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM01387	Small Cell Lung Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.G484S	SIDM01254	Burkitt's Lymphoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.1389
p.S492N	SIDM00783	Colorectal Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	0.7069
p.S492N	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGFVGS	DEG_SCF_TRCP1_1	0.7069
p.S492N	HCT-116	large_intestine	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z591	Microtubule organization protein AKNA	DEG_SCF_TRCP1_1	923:929	DSGFVGS	BTRC	0.9984	More...
Q9HBE5	Interleukin-21 receptor	DEG_SCF_TRCP1_1	491:497	DSGFVGS	BTRC	0.7908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGFVGS

Degron related mutations and impact score

Drug responses associated with IL21R mutations

All proteins holding degron of DSGFVGS