DegronMD

Uniprot ID: Q7Z591

Source protein: Microtubule organization protein AKNA

Source gene: AKNA

Class: DEG_Kelch_Keap1_1

Location: 82:87

E3 ligase: KEAP1

DEGRON score: 0.979

ASA_SCORE: 85.5667

COIL: 0.8765

CONS_SCORE: 0.4251

DSS_SCORE: 0.9649

HELIX: 0.1042

FCONS_SCORE: 1.2197

RIG_SCORE: 0.4902

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E96Q	TCGA-DK-A6B6	BLCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	0.0833
p.E96Q	DO48576	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.0833
p.G86V	TCGA-EM-A2CN	THCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	0.7532
p.G86V	DO39886	THCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7532
p.D97N	TCGA-UY-A78K	BLCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	0.0556
p.D97N	DO219031	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.0556
p.S85L	TCGA-YC-A89H	BLCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	0.8778
p.S85L	DO51948	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.8778
p.G87S	DO51883	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.6993
p.P84L	DO222990	BTCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO227999	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229010	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229016	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229003	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229005	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229353	LAML	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO230659	LAML	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO228941	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229028	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO229047	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO52365	LUSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.P84L	DO231036	LUSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7582
p.E91D	DO229013	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SIDM00305	Ovarian Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SIDM00555	Glioblastoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SIDM01196	Hepatocellular Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SIDM01770	Gastric Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	SNU-475	liver	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	KS-1	central_nervous_system	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.E91D	TE-1	oesophagus	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.S88Y	DO44440	HNSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.3056
p.H74N	DO229006	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.1111
p.E84K	SIDM00216	Colorectal Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.7022
p.E84K	ACH-000989	Colon/Colorectal Cancer	CCLE	DSESGE	DEG_Kelch_Keap1_1	0.7022
p.E92D	SIDM01608	Endometrial Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.1944
p.P75L	ACH-001547	Lung Cancer	CCLE	DSESGE	DEG_Kelch_Keap1_1	0.1389
p.P97L	DU-145	prostate	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.0556
p.A86V	OVK-18	ovary	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.6936
p.H74R	no-10	central_nervous_system	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11831	Serum response factor	DEG_Kelch_Keap1_1	82:87	DSESGE	KEAP1	0.996	More...
Q7Z591	Microtubule organization protein AKNA	DEG_Kelch_Keap1_1	82:87	DSESGE	KEAP1	0.979	More...
Q9NYF5	Protein FAM13B	DEG_Kelch_Keap1_1	492:497	DSESGE	KEAP1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSESGE

Degron related mutations and impact score

Drug responses associated with AKNA mutations

All proteins holding degron of DSESGE