DegronMD

Uniprot ID: Q9NYF5

Source protein: Protein FAM13B

Source gene: FAM13B

Class: DEG_Kelch_Keap1_1

Location: 492:497

E3 ligase: KEAP1

DEGRON score: 0.9932

ASA_SCORE: 83.5667

COIL: 0.791

CONS_SCORE: 0.4067

DSS_SCORE: 0.6764

HELIX: 0.1748

FCONS_SCORE: 1.1035

RIG_SCORE: 0.6247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M507I	TCGA-D8-A1X9	BRCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	0.0556
p.M507I	DO5472	BRCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.0556
p.E494K	TCGA-D8-A27G	BRCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	0.7022
p.E494K	DO5465	BRCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.7022
p.Q490K	DO229029	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.2778
p.S488P	ACH-001685	Lymphoma	CCLE	DSESGE	DEG_Kelch_Keap1_1	0.2222
p.A506S	ONS-76	central_nervous_system	COSMIC	DSESGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11831	Serum response factor	DEG_Kelch_Keap1_1	82:87	DSESGE	KEAP1	0.996	More...
Q7Z591	Microtubule organization protein AKNA	DEG_Kelch_Keap1_1	82:87	DSESGE	KEAP1	0.979	More...
Q9NYF5	Protein FAM13B	DEG_Kelch_Keap1_1	492:497	DSESGE	KEAP1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons