DegronMD - Q9NYF5(FAM13B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H704N	TCGA-AG-3892	READ	TCGA	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.0556
p.H704N	DO229015	LICA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.0556
p.H704N	DO36394	READ	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.0556
p.M507I	TCGA-D8-A1X9	BRCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation rewiring degron network	0.0556
p.M507I	DO5472	BRCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation rewiring degron network	0.0556
p.E494K	TCGA-D8-A27G	BRCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation altering degron motif	0.7022
p.E494K	DO5465	BRCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation altering degron motif	0.7022
p.R725M	TCGA-EY-A1GK	UCEC	TCGA	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.1944
p.R725M	DO42985	UCEC	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.1944
p.Q490K	DO229029	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation rewiring degron network	0.2778
p.Q722K	DO229035	LICA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.2778
p.R723K	DO220894	MELA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.25
p.E708D	DO229518	SKCA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.1667
p.P728H	DO37543	SKCM	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.1111
p.P728H	DO41572	UCEC	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.1111
p.K729R	SIDM00845	Burkitt's Lymphoma	GDSC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation substituting flanking lysine	0.1944
p.K729R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation substituting flanking lysine	0.1944
p.K729R	ACH-000786	Lymphoma	CCLE	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation substituting flanking lysine	0.1944
p.S488P	ACH-001685	Lymphoma	CCLE	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation rewiring degron network	0.2222
p.A704T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.0556
p.T722A	L-1236	haematopoietic and lymphoid tissue	COSMIC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	714:720	Mutation rewiring degron network	0.2778
p.A506S	ONS-76	central nervous system	COSMIC	DSESGE	DEG_Kelch_Keap1_1	492:497	Mutation rewiring degron network	0.0833

Kaplan plot for FAM13B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM13B

UniProt ID: Q9NYF5

Entrez ID: 51306

Protein name: Protein FAM13B (GAP-like protein N61)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM13B in