DegronMD

Uniprot ID: Q9NYF5

Source protein: Protein FAM13B

Source gene: FAM13B

Class: LIG_APCC_ABBAyCdc20_2

Location: 714:720

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7817

ASA_SCORE: 77.1571

COIL: 0.4436

CONS_SCORE: 0.5301

DSS_SCORE: 0.3741

HELIX: 0.5217

FCONS_SCORE: 1.0927

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H704N	TCGA-AG-3892	READ	TCGA	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.0556
p.H704N	DO229015	LICA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.0556
p.H704N	DO36394	READ	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R725M	TCGA-EY-A1GK	UCEC	TCGA	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R725M	DO42985	UCEC	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q722K	DO229035	LICA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R723K	DO220894	MELA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.25
p.E708D	DO229518	SKCA	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P728H	DO37543	SKCM	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P728H	DO41572	UCEC	ICGC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1111
p.K729R	SIDM00845	Burkitt's Lymphoma	GDSC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K729R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K729R	ACH-000786	Lymphoma	CCLE	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A704T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T722A	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	KSLLYYE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYF5	Protein FAM13B	LIG_APCC_ABBAyCdc20_2	714:720	KSLLYYE	APC,CDC20,FZR1	0.7817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons