DegronMD - P11831(SRF)

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; angiogenesis involved in wound healing [GO:0060055]; associative learning [GO:0008306]; bicellular tight junction assembly [GO:0070830]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus cartilage development [GO:0060532]; cardiac myofibril assembly [GO:0055003]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell-matrix adhesion [GO:0007160]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; developmental growth [GO:0048589]; dorsal aorta morphogenesis [GO:0035912]; epithelial cell-cell adhesion [GO:0090136]; epithelial structure maintenance [GO:0010669]; erythrocyte development [GO:0048821]; eyelid development in camera-type eye [GO:0061029]; face development [GO:0060324]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; hematopoietic stem cell differentiation [GO:0060218]; hippocampus development [GO:0021766]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; lung morphogenesis [GO:0060425]; lung smooth muscle development [GO:0061145]; megakaryocyte development [GO:0035855]; mesoderm formation [GO:0001707]; morphogenesis of an epithelial sheet [GO:0002011]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of miRNA transcription [GO:1902894]; neuron development [GO:0048666]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; platelet activation [GO:0030168]; platelet formation [GO:0030220]; positive regulation of axon extension [GO:0045773]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by glucose [GO:0046016]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003257]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; positive regulation of transcription via serum response element binding [GO:0010735]; positive thymic T cell selection [GO:0045059]; primitive streak formation [GO:0090009]; regulation of cell adhesion [GO:0030155]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of water loss via skin [GO:0033561]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; sarcomere organization [GO:0045214]; skin morphogenesis [GO:0043589]; stress fiber assembly [GO:0043149]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea cartilage development [GO:0060534]; trophectodermal cell differentiation [GO:0001829] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G294R	TCGA-13-0805	OV	TCGA	APSTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.G294V	TCGA-13-0805	OV	TCGA	APSTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.S296C	TCGA-66-2785	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.D245N	TCGA-B5-A1MX	UCEC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1111
p.D245Y	TCGA-BG-A0VX	UCEC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1111
p.D245Y	DO43923	UCEC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1111
p.L246F	TCGA-D3-A8GO	SKCM	TCGA	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1389
p.L246F	DO51242	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1389
p.T244R	TCGA-KQ-A41R	BLCA	TCGA	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0833
p.E252K	TCGA-UY-A9PE	BLCA	TCGA	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.3056
p.A268E	DO227982	COCA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0556
p.A268E	DO227982	COCA	ICGC	PGTTS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1944
p.G294C	DO228952	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.G97A	DO25040	LUAD	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0556
p.S92C	DO26520	LUSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.1944
p.G90V	DO28651	OV	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.25
p.G90R	DO28651	OV	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.25
p.Q245H	DO37595	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1111
p.T268I	SIDM01278	Colorectal Carcinoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0556
p.T268I	SIDM01278	Colorectal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1944
p.T244P	SIDM00845	Burkitt's Lymphoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0833
p.T244P	ACH-000992	Head and Neck Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0833
p.T244P	Daudi	haematopoietic and lymphoid tissue	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0833
p.S253C	SIDM00281	Other Solid Cancers	GDSC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation altering degron motif	0.8652
p.S253C	ACH-002100	Skin Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation altering degron motif	0.8652
p.S253C	DJM-1	skin	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	253:258	Mutation altering degron motif	0.8652
p.S77G	SIDM01118	Small Cell Lung Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation blocking phosphorylation signal	0.6389
p.G73R	ACH-000306	Non-Cancerous	CCLE	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0833

Kaplan plot for SRF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRF

UniProt ID: P11831

Entrez ID: 6722

Protein name: Serum response factor (SRF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRF in