DegronMD

Uniprot ID: P11831

Source protein: Serum response factor

Source gene: SRF

Class: DEG_Kelch_Keap1_1

Location: 253:258

E3 ligase: KEAP1

DEGRON score: 0.9273

ASA_SCORE: 84.0833

COIL: 0.8958

CONS_SCORE: 0.3144

DSS_SCORE: 0.607

HELIX: 0.0773

FCONS_SCORE: 0.8285

RIG_SCORE: 0.6177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D245N	TCGA-B5-A1MX	UCEC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.D245Y	TCGA-BG-A0VX	UCEC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.D245Y	DO43923	UCEC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.L246F	TCGA-D3-A8GO	SKCM	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1389
p.L246F	DO51242	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1389
p.T244R	TCGA-KQ-A41R	BLCA	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.0833
p.E252K	TCGA-UY-A9PE	BLCA	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.3056
p.A268E	DO227982	COCA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.0556
p.Q245H	DO37595	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.T268I	SIDM01278	Colorectal Carcinoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.0556
p.T244P	SIDM00845	Burkitt's Lymphoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.0833
p.T244P	ACH-000992	Head and Neck Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.0833
p.T244P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	0.0833
p.S253C	SIDM00281	Other Solid Cancers	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.8652
p.S253C	ACH-002100	Skin Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.8652
p.S253C	DJM-1	skin	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	0.8652

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11831	Serum response factor	DEG_Kelch_Keap1_1	253:258	SDSSGE	KEAP1	0.9273	More...
P23409	Myogenic factor 6	DEG_Kelch_Keap1_1	54:59	SDSSGE	KEAP1	0.9806	More...
Q8N841	Tubulin polyglutamylase TTLL6	DEG_Kelch_Keap1_1	768:773	SDSSGE	KEAP1	0.7156	More...
Q8ND07	Basal body-orientation factor 1	DEG_Kelch_Keap1_1	506:511	SDSSGE	KEAP1	0.9567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons