DegronMD

Uniprot ID: Q8N841

Source protein: Tubulin polyglutamylase TTLL6

Source gene: TTLL6

Class: DEG_Kelch_Keap1_1

Location: 768:773

E3 ligase: KEAP1

DEGRON score: 0.7156

ASA_SCORE: 79.4167

COIL: 0.7495

CONS_SCORE: 0.2578

DSS_SCORE: 0.5856

HELIX: 0.1685

FCONS_SCORE: 1.0086

RIG_SCORE: 0.5713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L763I	TCGA-34-5234	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.L763I	DO26810	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.K779R	TCGA-63-A5MV	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1667
p.K779R	DO219167	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1667
p.N759K	TCGA-90-A59Q	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.0833
p.N759K	DO50103	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.0833
p.S774F	TCGA-D3-A51T	SKCM	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.3056
p.S774F	DO47389	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.3056
p.L776I	DO229032	LICA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.25
p.E775K	SIDM00578	Neuroblastoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.2778
p.E775K	ACH-000804	Neuroblastoma	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.2778
p.E775K	NB1	autonomic_ganglia	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	0.2778
p.I773M	ACH-000267	Lymphoma	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.7618
p.I773M	ACH-000755	Breast Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.7618
p.I773M	ACH-001321	Thyroid Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11831	Serum response factor	DEG_Kelch_Keap1_1	253:258	SDSSGE	KEAP1	0.9273	More...
P23409	Myogenic factor 6	DEG_Kelch_Keap1_1	54:59	SDSSGE	KEAP1	0.9806	More...
Q8N841	Tubulin polyglutamylase TTLL6	DEG_Kelch_Keap1_1	768:773	SDSSGE	KEAP1	0.7156	More...
Q8ND07	Basal body-orientation factor 1	DEG_Kelch_Keap1_1	506:511	SDSSGE	KEAP1	0.9567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons