DegronMD

Uniprot ID: P23409

Source protein: Myogenic factor 6

Source gene: MYF6

Class: DEG_Kelch_Keap1_1

Location: 54:59

E3 ligase: KEAP1

DEGRON score: 0.9806

ASA_SCORE: 76.8333

COIL: 0.8853

CONS_SCORE: 0.6048

DSS_SCORE: 0.7594

HELIX: 0.093

FCONS_SCORE: 1.0988

RIG_SCORE: 0.5311

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D55V	TCGA-60-2719	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.6674
p.D55V	DO27453	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.6674
p.P50L	TCGA-85-A511	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.P50L	TCGA-A6-5660	COAD	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.P50L	DO7972	COAD	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.P50L	DO45509	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.D55G	TCGA-AA-3947	COAD	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.6087
p.D55G	DO8192	COAD	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.6087
p.A64V	TCGA-BS-A0TA	UCEC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.A64V	TCGA-FF-8042	DLBC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.A64V	TCGA-VS-A9UV	CESC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.A64V	DO219741	CESC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.A64V	DO222306	DLBC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.A64V	DO43298	UCEC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.D55N	TCGA-C5-A8XK	CESC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.5821
p.D55N	DO49904	CESC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.5821
p.P50T	TCGA-CN-A6V3	HNSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.P50T	DO52050	HNSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.E59K	TCGA-DA-A1HV	SKCM	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.7022
p.E59K	DO37659	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.7022
p.S56I	TCGA-EO-A22U	UCEC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.7341
p.S56I	DO43755	UCEC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.7341
p.P49S	TCGA-FU-A3HZ	CESC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.P49S	DO6308	CESC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q69R	DO217818	GACA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.0556
p.E51D	DO233906	GACA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.25
p.C44F	DO229009	LICA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.0556
p.P66R	DO228253	MALY	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.1389
p.E51K	DO222595	MELA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.25
p.L63V	DO222595	MELA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	0.2222
p.V62I	SIDM00417	Plasma Cell Myeloma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.25
p.V62I	SIDM00526	Chronic Myelogenous Leukemia	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.25
p.V62I	SIDM00196	Ewing's Sarcoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.25
p.G67V	SIDM00510	Small Cell Lung Carcinoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.G67V	ACH-002095	Lung Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.G67V	COR-L303	lung	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	0.1111
p.P66Q	SIDM00143	Small Cell Lung Carcinoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.1389
p.P66Q	ACH-000803	Lung Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	0.1389
p.P66Q	COLO-668	lung	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	0.1389
p.G58R	SIDM00280	Gastric Carcinoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	0.7568
p.G58R	ECC10	stomach	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11831	Serum response factor	DEG_Kelch_Keap1_1	253:258	SDSSGE	KEAP1	0.9273	More...
P23409	Myogenic factor 6	DEG_Kelch_Keap1_1	54:59	SDSSGE	KEAP1	0.9806	More...
Q8N841	Tubulin polyglutamylase TTLL6	DEG_Kelch_Keap1_1	768:773	SDSSGE	KEAP1	0.7156	More...
Q8ND07	Basal body-orientation factor 1	DEG_Kelch_Keap1_1	506:511	SDSSGE	KEAP1	0.9567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SDSSGE

Degron related mutations and impact score

Drug responses associated with MYF6 mutations

All proteins holding degron of SDSSGE