DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SDSSGE
Uniprot ID:
Q8ND07
Source protein:
Basal body-orientation factor 1
Source gene:
BBOF1
Class:
DEG_Kelch_Keap1_1
Location:
506:511
E3 ligase:
KEAP1
DEGRON score:
0.9567
ASA_SCORE:
80.0667
COIL:
0.884
CONS_SCORE:
0.7267
DSS_SCORE:
0.4123
HELIX:
0.0478
FCONS_SCORE:
1.0192
RIG_SCORE:
0.7039
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with BBOF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SDSSGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P11831
Serum response factor
DEG_Kelch_Keap1_1
253:258
SDSSGE
KEAP1
0.9273
More...
P23409
Myogenic factor 6
DEG_Kelch_Keap1_1
54:59
SDSSGE
KEAP1
0.9806
More...
Q8N841
Tubulin polyglutamylase TTLL6
DEG_Kelch_Keap1_1
768:773
SDSSGE
KEAP1
0.7156
More...
Q8ND07
Basal body-orientation factor 1
DEG_Kelch_Keap1_1
506:511
SDSSGE
KEAP1
0.9567
More...