DegronMD - Q8N841(TTLL6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L763I	TCGA-34-5234	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.1944
p.L763I	DO26810	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.1944
p.K779R	TCGA-63-A5MV	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.1667
p.K779R	DO219167	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.1667
p.N759K	TCGA-90-A59Q	LUSC	TCGA	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.0833
p.N759K	DO50103	LUSC	ICGC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.0833
p.S774F	TCGA-D3-A51T	SKCM	TCGA	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.3056
p.S774F	DO47389	SKCM	ICGC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.3056
p.E449K	TCGA-EE-A29N	SKCM	TCGA	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.1389
p.L776I	DO229032	LICA	ICGC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.25
p.C442Y	SIDM01169	Ovarian Carcinoma	GDSC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation altering degron motif	0.5976
p.C442Y	ACH-000885	Ovarian Cancer	CCLE	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation altering degron motif	0.5976
p.C442Y	TOV-21G	ovary	COSMIC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation altering degron motif	0.5976
p.E440K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation altering degron motif	0.7022
p.E440K	ACH-002238	Leukemia	CCLE	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation altering degron motif	0.7022
p.E440K	GR-ST	haematopoietic and lymphoid tissue	COSMIC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation altering degron motif	0.7022
p.E775K	SIDM00578	Neuroblastoma	GDSC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.2778
p.E775K	ACH-000804	Neuroblastoma	CCLE	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.2778
p.E775K	NB1	autonomic ganglia	COSMIC	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation rewiring degron network	0.2778
p.I773M	ACH-000267	Lymphoma	CCLE	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation altering degron motif	0.7618
p.I773M	ACH-000755	Breast Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation altering degron motif	0.7618
p.I773M	ACH-001321	Thyroid Cancer	CCLE	SDSSGE	DEG_Kelch_Keap1_1	768:773	Mutation altering degron motif	0.7618
p.P449A	KELLY	autonomic ganglia	COSMIC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.1389
p.W446C	RERF-LC-KJ	lung	COSMIC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.2222
p.W446S	RERF-LC-KJ	lung	COSMIC	EKENC	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.2222

Kaplan plot for TTLL6 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTLL6

UniProt ID: Q8N841

Entrez ID: 284076

Protein name: Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TTLL6 in