DegronMD

Uniprot ID: Q8N841

Source protein: Tubulin polyglutamylase TTLL6

Source gene: TTLL6

Class: DEG_APCC_KENBOX_2

Location: 438:442

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5048

ASA_SCORE: 75.36

COIL: 0.2644

CONS_SCORE: 0.4096

DSS_SCORE: 0.2124

HELIX: 0.723

FCONS_SCORE: 1.1662

RIG_SCORE: 0.8053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E449K	TCGA-EE-A29N	SKCM	TCGA	EKENC	DEG_APCC_KENBOX_2	0.1389
p.C442Y	SIDM01169	Ovarian Carcinoma	GDSC	EKENC	DEG_APCC_KENBOX_2	0.5976
p.C442Y	ACH-000885	Ovarian Cancer	CCLE	EKENC	DEG_APCC_KENBOX_2	0.5976
p.C442Y	TOV-21G	ovary	COSMIC	EKENC	DEG_APCC_KENBOX_2	0.5976
p.E440K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	EKENC	DEG_APCC_KENBOX_2	0.7022
p.E440K	ACH-002238	Leukemia	CCLE	EKENC	DEG_APCC_KENBOX_2	0.7022
p.E440K	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	EKENC	DEG_APCC_KENBOX_2	0.7022
p.P449A	KELLY	autonomic_ganglia	COSMIC	EKENC	DEG_APCC_KENBOX_2	0.1389
p.W446C	RERF-LC-KJ	lung	COSMIC	EKENC	DEG_APCC_KENBOX_2	0.2222
p.W446S	RERF-LC-KJ	lung	COSMIC	EKENC	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N841	Tubulin polyglutamylase TTLL6	DEG_APCC_KENBOX_2	438:442	EKENC	APC,CDC20,FZR1	0.5048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons