DegronMD

Uniprot ID: P11831

Source protein: Serum response factor

Source gene: SRF

Class: DEG_Kelch_Keap1_1

Location: 82:87

E3 ligase: KEAP1

DEGRON score: 0.996

ASA_SCORE: 85.5167

COIL: 0.7872

CONS_SCORE: 0.3552

DSS_SCORE: 0.7179

HELIX: 0.1912

FCONS_SCORE: 1.1227

RIG_SCORE: 0.579

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G97A	DO25040	LUAD	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.0556
p.S92C	DO26520	LUSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.1944
p.G90V	DO28651	OV	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.25
p.G90R	DO28651	OV	ICGC	DSESGE	DEG_Kelch_Keap1_1	0.25
p.S77G	SIDM01118	Small Cell Lung Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	0.6389
p.G73R	ACH-000306	Non-Cancerous	CCLE	DSESGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11831	Serum response factor	DEG_Kelch_Keap1_1	82:87	DSESGE	KEAP1	0.996	More...
Q7Z591	Microtubule organization protein AKNA	DEG_Kelch_Keap1_1	82:87	DSESGE	KEAP1	0.979	More...
Q9NYF5	Protein FAM13B	DEG_Kelch_Keap1_1	492:497	DSESGE	KEAP1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons