DegronMD

Uniprot ID: Q7Z591

Source protein: Microtubule organization protein AKNA

Source gene: AKNA

Class: LIG_APCC_ABBA_1

Location: 473:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8303

ASA_SCORE: 82.8

COIL: 0.8283

CONS_SCORE: 0.6477

DSS_SCORE: 0.4562

HELIX: 0.0673

FCONS_SCORE: 0.9201

RIG_SCORE: 0.7262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F476L	TCGA-A5-A1OF	UCEC	TCGA	VNLFSD	LIG_APCC_ABBA_1	0.6981
p.F476L	DO42568	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.6981
p.T488M	TCGA-AP-A059	UCEC	TCGA	VNLFSD	LIG_APCC_ABBA_1	0.0556
p.T488M	DO233867	GACA	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.0556
p.T488M	DO41361	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.0556
p.Q466K	DO229008	LICA	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.1389
p.A466E	DO41959	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.1389
p.E478K	DO42753	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.7022
p.R473Q	DO42633	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	0.7329
p.R473Q	JHOS-4	ovary	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.7329
p.R473Q	KMH-2	thyroid	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.7329
p.S485N	SIDM01117	Small Cell Lung Carcinoma	GDSC	VNLFSD	LIG_APCC_ABBA_1	0.1389
p.H484Y	SIDM00722	Mesothelioma	GDSC	VNLFSD	LIG_APCC_ABBA_1	0.1667
p.H484Y	ACH-000092	Lung Cancer	CCLE	VNLFSD	LIG_APCC_ABBA_1	0.1667
p.H484Y	NCI-H2452	pleura	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.1667
p.V473L	SIDM00396	Acute Myeloid Leukemia	GDSC	VNLFSD	LIG_APCC_ABBA_1	0.5654
p.V473L	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.5654
p.P482S	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VNLFSD	LIG_APCC_ABBA_1	0.2222
p.P482S	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.2222
p.D478G	SIDM00217	Colorectal Carcinoma	GDSC	VNLFSD	LIG_APCC_ABBA_1	0.7198
p.D478G	ACH-000999	Colon/Colorectal Cancer	CCLE	VNLFSD	LIG_APCC_ABBA_1	0.7198
p.D478G	SNU-1040	large_intestine	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.7198
p.A476T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.7139
p.A486T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z591	Microtubule organization protein AKNA	LIG_APCC_ABBA_1	473:478	VNLFSD	APC,CDC20,FZR1	0.8303	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VNLFSD

Degron related mutations and impact score

Drug responses associated with AKNA mutations

All proteins holding degron of VNLFSD