DegronMD - P10253(GAA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P131S	TCGA-AP-A1DK	UCEC	TCGA	PPSY	ITCH	130:133	Mutation altering degron motif	0.6752
p.P131S	DO42033	UCEC	ICGC	PPSY	ITCH	130:133	Mutation altering degron motif	0.6752
p.Q124H	TCGA-DX-A6YT	SARC	TCGA	PPSY	ITCH	130:133	Mutation rewiring degron network	0.1667
p.Q124H	DO220007	SARC	ICGC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.1667
p.P134L	TCGA-ER-A19D	SKCM	TCGA	PPSY	ITCH	130:133	Mutation rewiring degron network	0.3056
p.P134L	DO37750	SKCM	ICGC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.3056
p.R870Q	TCGA-GD-A6C6	BLCA	TCGA	RGELFWD	LIG_APCC_ABBAyCdc20_2	854:860	Mutation rewiring degron network	0.0556
p.R870Q	DO48504	BLCA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	854:860	Mutation rewiring degron network	0.0556
p.D861N	DO228976	LICA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	854:860	Mutation rewiring degron network	0.3056
p.R870L	DO228976	LICA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	854:860	Mutation rewiring degron network	0.0556
p.G850V	DO229015	LICA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	854:860	Mutation rewiring degron network	0.2222
p.C127F	DO229024	LICA	ICGC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.25
p.W126L	DO229006	LICA	ICGC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.2222
p.S143F	DO222880	MELA	ICGC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.0556
p.G862V	DO232838	NACA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	854:860	Mutation rewiring degron network	0.2778
p.S132G	DO229264	THCA	ICGC	PPSY	ITCH	130:133	Mutation altering degron motif	0.5882
p.L138M	SIDM00783	Colorectal Carcinoma	GDSC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.1944
p.L138M	ACH-000971	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	130:133	Mutation rewiring degron network	0.1944
p.L138M	HCT-116	large intestine	COSMIC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.1944
p.W126R	SIDM01611	Endometrial Carcinoma	GDSC	PPSY	ITCH	130:133	Mutation rewiring degron network	0.2222
p.W126R	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	130:133	Mutation rewiring degron network	0.2222
p.Y136N	ACH-000215	Brain Cancer	CCLE	PPSY	ITCH	130:133	Mutation rewiring degron network	0.25

Kaplan plot for GAA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAA

UniProt ID: P10253

Entrez ID: 2548

Protein name: Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAA in