DegronMD

Uniprot ID: P10253

Source protein: Lysosomal alpha-glucosidase

Source gene: GAA

Class: LIG_APCC_ABBAyCdc20_2

Location: 854:860

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8263

ASA_SCORE: 30.2143

COIL: 0.0719

CONS_SCORE: 0.5035

DSS_SCORE: 0.3165

HELIX: 0.0057

FCONS_SCORE: 1.4716

RIG_SCORE: 0.8093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R870Q	TCGA-GD-A6C6	BLCA	TCGA	RGELFWD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R870Q	DO48504	BLCA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D861N	DO228976	LICA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R870L	DO228976	LICA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G850V	DO229015	LICA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G862V	DO232838	NACA	ICGC	RGELFWD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10253	Lysosomal alpha-glucosidase	LIG_APCC_ABBAyCdc20_2	854:860	RGELFWD	APC,CDC20,FZR1	0.8263	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons