DegronMD - Q9NY46(SCN3A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N1882K	TCGA-17-Z028	LUAD	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.1111
p.S1972R	TCGA-50-5941	LUAD	TCGA	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.2778
p.S1881L	TCGA-A5-A0G2	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0833
p.S1881L	DO41235	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0833
p.S1881P	TCGA-A5-A1OF	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0833
p.S1881P	DO42568	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0833
p.R1897H	TCGA-AA-3977	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.R1897H	TCGA-CG-4460	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.R1897H	SIDM00491	Thyroid Gland Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.R1897H	ACH-001443	Thyroid Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.R1897H	ASH-3	thyroid	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.G1141E	TCGA-DA-A1HV	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.2778
p.G1141E	SIDM00081	Melanoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.2778
p.G1141E	ACH-000615	Skin Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.2778
p.G1141E	SK-MEL-28	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.2778
p.D1959N	TCGA-DX-AB2E	SARC	TCGA	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.1111
p.A1880V	TCGA-EA-A410	CESC	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.A1880V	DO49929	CESC	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.S1129N	TCGA-EE-A2GR	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1667
p.S1129N	DO37996	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1667
p.S1972C	TCGA-LP-A4AW	CESC	TCGA	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.2778
p.T1893I	TCGA-W3-A828	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation altering degron motif	0.8189
p.T1893I	DO51273	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation altering degron motif	0.8189
p.T1893I	SIDM00581	Glioblastoma	GDSC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation altering degron motif	0.8189
p.T1893I	ACH-000738	Brain Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation altering degron motif	0.8189
p.T1893I	GB-1	central nervous system	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation altering degron motif	0.8189
p.S1969F	TCGA-YD-A89C	SKCM	TCGA	PPSY	ITCH	1967:1970	Mutation altering degron motif	0.6871
p.S1969F	DO219501	SKCM	ICGC	PPSY	ITCH	1967:1970	Mutation altering degron motif	0.6871
p.S1969F	SIDM00189	Melanoma	GDSC	PPSY	ITCH	1967:1970	Mutation altering degron motif	0.6871
p.S1969F	ACH-002098	Skin Cancer	CCLE	PPSY	ITCH	1967:1970	Mutation altering degron motif	0.6871
p.S1969F	CP67-MEL	skin	COSMIC	PPSY	ITCH	1967:1970	Mutation altering degron motif	0.6871
p.A1880P	DO224746	BRCA	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.A1880P	DO52543	BRCA	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.D1898H	DO51632	CESC	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation substituting flanking lysine	0.3333
p.F1130L	DO10880	GBM	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation substituting flanking lysine	0.3056
p.L1146V	DO223667	LGG	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1389
p.L1126I	DO228969	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.0833
p.L1126I	DO229032	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.0833
p.A1880E	DO228976	LICA	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.D1977E	DO229038	LICA	ICGC	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.1389
p.G1885R	DO222420	MELA	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation substituting flanking lysine	0.3056
p.S1904F	DO222843	MELA	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.M1895I	DO218847	SKCA	ICGC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.3056
p.R1147Q	DO37831	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1111
p.R1147Q	DO37746	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1111
p.R1147Q	DO51259	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1111
p.A1904V	SIDM01314	Colorectal Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.R1897C	SIDM00890	Melanoma	GDSC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.R1897C	ACH-000580	Skin Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.R1897C	C32	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.25
p.E1900Q	SIDM00995	Other Solid Cancers	GDSC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.1667
p.E1900Q	ACH-001328	Skin Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.1667
p.E1900Q	A431	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.1667
p.A1135T	SIDM00217	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation altering degron motif	0.7139
p.A1135T	ACH-000999	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation altering degron motif	0.7139
p.A1135T	SNU-1040	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation altering degron motif	0.7139
p.E1979K	ACH-000968	Skin Cancer	CCLE	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.0833
p.E1979K	COLO-792	skin	COSMIC	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.0833
p.K1896M	NCI-H1436	lung	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.2778
p.N1145D	NCI-H358	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	1135:1139	Mutation rewiring degron network	0.1667
p.K1899T	THP-1	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.1944
p.S1904Y	SNU-1040	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1890:1894	Mutation rewiring degron network	0.0556
p.E1958K	COLO-792	skin	COSMIC	PPSY	ITCH	1967:1970	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN3A

UniProt ID: Q9NY46

Entrez ID: 6328

Protein name: Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SCN3A in