DegronMD - Q9UPR6(ZFR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T196N	TCGA-2G-AAKG	TGCT	TCGA	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.A180V	TCGA-78-8662	LUAD	TCGA	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1111
p.A180V	DO45346	LUAD	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1111
p.A197T	TCGA-B0-5713	KIRC	TCGA	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1667
p.A197T	DO17216	KIRC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1667
p.G133W	TCGA-BF-A1Q0	SKCM	TCGA	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1944
p.G133W	DO47374	SKCM	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1944
p.C132S	TCGA-KB-A6F5	STAD	TCGA	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.2222
p.C132S	DO50128	STAD	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.2222
p.S190F	TCGA-XV-A9W5	SKCM	TCGA	PPSY	ITCH	188:191	Mutation altering degron motif	0.6871
p.S190F	DO219491	SKCM	ICGC	PPSY	ITCH	188:191	Mutation altering degron motif	0.6871
p.V183M	DO230334	COCA	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO229010	COCA	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO229489	LAML	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO228941	LICA	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO230979	LUSC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO52365	LUSC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO231051	LUSC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO231075	LUSC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO231049	LUSC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.V183M	DO231102	LUSC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.Y198H	DO222798	COCA	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1389
p.P188Q	DO229019	LICA	ICGC	PPSY	ITCH	188:191	Mutation altering degron motif	0.7035
p.P135T	DO229029	LICA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1389
p.I182T	DO231636	LINC	ICGC	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1667
p.G127E	DO220873	MELA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation altering degron motif	0.6087
p.P126T	DO232224	PBCA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation altering degron motif	0.5919
p.A121T	DO232224	PBCA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.3056
p.L113I	DO36556	READ	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.0833
p.P188L	DO229240	THCA	ICGC	PPSY	ITCH	188:191	Mutation altering degron motif	0.7582
p.R117C	SIDM01307	Colorectal Carcinoma	GDSC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1944
p.G133R	SIDM01113	Other Sarcomas	GDSC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1944
p.G133R	ACH-000939	Sarcoma	CCLE	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1944
p.G133R	SK-UT-1	soft tissue	COSMIC	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation rewiring degron network	0.1944
p.T199M	ACH-000932	Gastric Cancer	CCLE	PPSY	ITCH	188:191	Mutation rewiring degron network	0.1111
p.D122H	ACH-001511	Head and Neck Cancer	CCLE	DSGQPGT	DEG_SCF_TRCP1_1	122:128	Mutation altering degron motif	0.7688

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFR2

UniProt ID: Q9UPR6

Entrez ID: 23217

Protein name: Zinc finger RNA-binding protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFR2 in