DegronMD

Uniprot ID: Q9UPR6

Source protein: Zinc finger RNA-binding protein 2

Source gene: ZFR2

Class: DEG_SCF_TRCP1_1

Location: 122:128

E3 ligase: BTRC

DEGRON score: 0.9823

ASA_SCORE: 66.7571

COIL: 0.8766

CONS_SCORE: 0.2422

DSS_SCORE: 0.7138

HELIX: 0.0367

FCONS_SCORE: 1.0496

RIG_SCORE: 0.5433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G133W	TCGA-BF-A1Q0	SKCM	TCGA	DSGQPGT	DEG_SCF_TRCP1_1	0.1944
p.G133W	DO47374	SKCM	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.1944
p.C132S	TCGA-KB-A6F5	STAD	TCGA	DSGQPGT	DEG_SCF_TRCP1_1	0.2222
p.C132S	DO50128	STAD	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.2222
p.P135T	DO229029	LICA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.1389
p.G127E	DO220873	MELA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.6087
p.P126T	DO232224	PBCA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.5919
p.A121T	DO232224	PBCA	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.3056
p.L113I	DO36556	READ	ICGC	DSGQPGT	DEG_SCF_TRCP1_1	0.0833
p.R117C	SIDM01307	Colorectal Carcinoma	GDSC	DSGQPGT	DEG_SCF_TRCP1_1	0.1944
p.G133R	SIDM01113	Other Sarcomas	GDSC	DSGQPGT	DEG_SCF_TRCP1_1	0.1944
p.G133R	ACH-000939	Sarcoma	CCLE	DSGQPGT	DEG_SCF_TRCP1_1	0.1944
p.G133R	SK-UT-1	soft_tissue	COSMIC	DSGQPGT	DEG_SCF_TRCP1_1	0.1944
p.D122H	ACH-001511	Head and Neck Cancer	CCLE	DSGQPGT	DEG_SCF_TRCP1_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPR6	Zinc finger RNA-binding protein 2	DEG_SCF_TRCP1_1	122:128	DSGQPGT	BTRC	0.9823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons