DegronMD - A6NKD9(CCDC85C)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A242T	DO233709	GACA	ICGC	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.3056
p.H307N	DO229045	LICA	ICGC	PPSY	ITCH	316:319	Mutation rewiring degron network	0.0833
p.P316Q	DO229006	LICA	ICGC	PPSY	ITCH	316:319	Mutation altering degron motif	0.7035
p.A328T	DO232224	PBCA	ICGC	PPSY	ITCH	316:319	Mutation rewiring degron network	0.0833
p.S258N	DO42673	UCEC	ICGC	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation blocking phosphorylation signal	0.5833
p.H256R	ACH-000966	Ovarian Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.1944
p.R257H	ACH-000983	Leukemia	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.1667
p.A252V	ACH-000996	Endometrial/Uterine Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.3056
p.A252P	ACH-001814	Bone Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.3056
p.S251A	ACH-001814	Bone Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.6477
p.N325D	ACH-001818	Bone Cancer	CCLE	PPSY	ITCH	316:319	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons