DegronMD

Uniprot ID: A6NKD9

Source protein: Coiled-coil domain-containing protein 85C

Source gene: CCDC85C

Class: DEG_APCC_DBOX_1

Location: 243:251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8632

ASA_SCORE: 92.9111

COIL: 0.6911

CONS_SCORE: 0.468

DSS_SCORE: 0.7697

HELIX: 0.2454

FCONS_SCORE: 1.2373

RIG_SCORE: 0.6269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A242T	DO233709	GACA	ICGC	TRRSLDDLS	DEG_APCC_DBOX_1	0.3056
p.S258N	DO42673	UCEC	ICGC	TRRSLDDLS	DEG_APCC_DBOX_1	0.5833
p.H256R	ACH-000966	Ovarian Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	0.1944
p.R257H	ACH-000983	Leukemia	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	0.1667
p.A252V	ACH-000996	Endometrial/Uterine Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	0.3056
p.A252P	ACH-001814	Bone Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	0.3056
p.S251A	ACH-001814	Bone Cancer	CCLE	TRRSLDDLS	DEG_APCC_DBOX_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKD9	Coiled-coil domain-containing protein 85C	DEG_APCC_DBOX_1	243:251	TRRSLDDLS	APC,CDC20,FZR1	0.8632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons