DegronMD - O60481(ZIC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N29K	TCGA-34-5232	LUSC	TCGA	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1111
p.N29K	DO27168	LUSC	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1111
p.R30S	TCGA-34-5232	LUSC	TCGA	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1389
p.R30S	DO27168	LUSC	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1389
p.P163H	TCGA-55-6983	LUAD	TCGA	PPSY	ITCH	156:159	Mutation rewiring degron network	0.2222
p.P163H	DO23643	LUAD	ICGC	PPSY	ITCH	156:159	Mutation rewiring degron network	0.2222
p.P32L	TCGA-A5-A1OF	UCEC	TCGA	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1944
p.P32L	DO42568	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1944
p.G164E	TCGA-AA-3854	COAD	TCGA	PPSY	ITCH	156:159	Mutation rewiring degron network	0.1944
p.G164E	DO10148	COAD	ICGC	PPSY	ITCH	156:159	Mutation rewiring degron network	0.1944
p.H148N	TCGA-CV-A45X	HNSC	TCGA	PPSY	ITCH	156:159	Mutation rewiring degron network	0.1111
p.H148N	DO52062	HNSC	ICGC	PPSY	ITCH	156:159	Mutation rewiring degron network	0.1111
p.G41R	TCGA-EC-A24G	UCEC	TCGA	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation altering degron motif	0.6457
p.G41R	DO40996	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation altering degron motif	0.6457
p.Q168H	TCGA-EE-A2M8	SKCM	TCGA	PPSY	ITCH	156:159	Mutation rewiring degron network	0.0833
p.Q168H	DO38075	SKCM	ICGC	PPSY	ITCH	156:159	Mutation rewiring degron network	0.0833
p.R30C	TCGA-FI-A2D0	UCEC	TCGA	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1389
p.R30C	DO43891	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1389
p.P157L	TCGA-FW-A3R5	SKCM	TCGA	PPSY	ITCH	156:159	Mutation altering degron motif	0.7582
p.P157L	DO37406	SKCM	ICGC	PPSY	ITCH	156:159	Mutation altering degron motif	0.7582
p.P157L	SIDM02026	Colorectal Carcinoma	GDSC	PPSY	ITCH	156:159	Mutation altering degron motif	0.7582
p.A33V	DO224987	BRCA	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A33V	DO229489	LAML	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.R30H	DO44095	COAD	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1389
p.G152D	DO233203	GACA	ICGC	PPSY	ITCH	156:159	Mutation rewiring degron network	0.2222
p.A52T	DO42673	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.0556
p.A52T	ACH-000988	Endometrial/Uterine Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.0556
p.A33S	SIDM01133	Other Solid Cancers	GDSC	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A33S	ACH-002177	Lung Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A51T	ACH-001669	Leukemia	CCLE	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.0833
p.A52P	ACH-001669	Leukemia	CCLE	LNPFGD	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.0556

Kaplan plot for ZIC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZIC3

UniProt ID: O60481

Entrez ID: 7547

Protein name: Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZIC3 in