DegronMD

Uniprot ID: O60481

Source protein: Zinc finger protein ZIC 3

Source gene: ZIC3

Class: LIG_APCC_ABBA_1

Location: 37:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8678

ASA_SCORE: 48.0167

COIL: 0.8113

CONS_SCORE: 0.435

DSS_SCORE: 0.5068

HELIX: 0.1135

FCONS_SCORE: 1.0846

RIG_SCORE: 0.6489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N29K	TCGA-34-5232	LUSC	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.1111
p.N29K	DO27168	LUSC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1111
p.R30S	TCGA-34-5232	LUSC	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.R30S	DO27168	LUSC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.P32L	TCGA-A5-A1OF	UCEC	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.1944
p.P32L	DO42568	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1944
p.G41R	TCGA-EC-A24G	UCEC	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.6457
p.G41R	DO40996	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.6457
p.R30C	TCGA-FI-A2D0	UCEC	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.R30C	DO43891	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.A33V	DO224987	BRCA	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.A33V	DO229489	LAML	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.R30H	DO44095	COAD	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.A52T	DO42673	UCEC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.0556
p.A52T	ACH-000988	Endometrial/Uterine Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.0556
p.A33S	SIDM01133	Other Solid Cancers	GDSC	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.A33S	ACH-002177	Lung Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.A51T	ACH-001669	Leukemia	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.0833
p.A52P	ACH-001669	Leukemia	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons