DegronMD

Uniprot ID: Q8NDI1

Source protein: EH domain-binding protein 1

Source gene: EHBP1

Class: LIG_APCC_ABBA_1

Location: 278:283

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.998

ASA_SCORE: 68.45

COIL: 0.9007

CONS_SCORE: 0.3882

DSS_SCORE: 0.8013

HELIX: 0.0512

FCONS_SCORE: 1.1392

RIG_SCORE: 0.6215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E292K	TCGA-EL-A3CT	THCA	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.0833
p.E292K	DO48113	THCA	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.0833
p.P269S	TCGA-FS-A1Z3	SKCM	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.0833
p.P269S	DO37635	SKCM	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.0833
p.P273S	TCGA-W3-AA1V	SKCM	TCGA	LNPFGD	LIG_APCC_ABBA_1	0.1944
p.P273S	DO230529	LUSC	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1944
p.P273S	DO51276	SKCM	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.1944
p.P269L	DO220877	MELA	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.0833
p.P280L	DO220886	MELA	ICGC	LNPFGD	LIG_APCC_ABBA_1	0.6471
p.A275V	SIDM01088	Endometrial Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	0.25
p.A275V	ACH-000965	Endometrial/Uterine Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.25
p.A275V	RL95-2	endometrium	COSMIC	LNPFGD	LIG_APCC_ABBA_1	0.25
p.D274V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.D274V	ACH-000951	Lung Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.D274V	NCI-H2342	lung	COSMIC	LNPFGD	LIG_APCC_ABBA_1	0.2222
p.D271N	SIDM00241	Breast Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.D271N	ACH-002179	Breast Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.D271N	OCUB-M	breast	COSMIC	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.N268Y	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	0.0556
p.I290V	ACH-001380	Pancreatic Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	0.1389
p.N271K	KELLY	autonomic_ganglia	COSMIC	LNPFGD	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons