DegronMD - Q8NDI1(EHBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E313D	TCGA-A5-A0G2	UCEC	TCGA	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1389
p.E313D	DO41235	UCEC	ICGC	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1389
p.S335Y	TCGA-AX-A2HC	UCEC	TCGA	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5
p.S335Y	DO41572	UCEC	ICGC	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5
p.V621A	TCGA-EE-A3J5	SKCM	TCGA	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.5825
p.V621A	TCGA-YD-A9TA	SKCM	TCGA	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.5825
p.V621A	DO47331	SKCM	ICGC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.5825
p.V621A	DO219503	SKCM	ICGC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.5825
p.E292K	TCGA-EL-A3CT	THCA	TCGA	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.0833
p.E292K	DO48113	THCA	ICGC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.0833
p.P269S	TCGA-FS-A1Z3	SKCM	TCGA	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.0833
p.P269S	DO37635	SKCM	ICGC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.0833
p.I332M	TCGA-UY-A9PA	BLCA	TCGA	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1389
p.I332M	DO219040	BLCA	ICGC	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1389
p.P273S	TCGA-W3-AA1V	SKCM	TCGA	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1944
p.P273S	DO230529	LUSC	ICGC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1944
p.P273S	DO51276	SKCM	ICGC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1944
p.G626V	DO219071	HNSC	ICGC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation rewiring degron network	0.2778
p.G622V	DO229031	LICA	ICGC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.6421
p.R627M	DO229035	LICA	ICGC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation rewiring degron network	0.25
p.Q318H	DO229044	LICA	ICGC	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.2778
p.A328T	DO23440	LINC	ICGC	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.25
p.P269L	DO220877	MELA	ICGC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.0833
p.P280L	DO220886	MELA	ICGC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation altering degron motif	0.6471
p.G620R	SIDM00789	Colorectal Carcinoma	GDSC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.7568
p.A275V	SIDM01088	Endometrial Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.25
p.A275V	ACH-000965	Endometrial/Uterine Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.25
p.A275V	RL95-2	endometrium	COSMIC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.25
p.D274V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.2222
p.D274V	ACH-000951	Lung Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.2222
p.D274V	NCI-H2342	lung	COSMIC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.2222
p.D271N	SIDM00241	Breast Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1389
p.D271N	ACH-002179	Breast Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1389
p.D271N	OCUB-M	breast	COSMIC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1389
p.N268Y	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.0556
p.K333N	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation substituting flanking lysine	0.2222
p.K333N	ACH-000845	Lung Cancer	CCLE	LNPFDE	LIG_APCC_ABBA_1	320:325	Mutation substituting flanking lysine	0.2222
p.I290V	ACH-001380	Pancreatic Cancer	CCLE	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1389
p.N271K	KELLY	autonomic ganglia	COSMIC	LNPFGD	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1389
p.S621C	U031	kidney	COSMIC	DSGVGES	DEG_SCF_TRCP1_1	618:624	Mutation altering degron motif	0.7541

Kaplan plot for EHBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EHBP1

UniProt ID: Q8NDI1

Entrez ID: 23301

Protein name: EH domain-binding protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EHBP1 in