DegronMD

Uniprot ID: Q8NDI1

Source protein: EH domain-binding protein 1

Source gene: EHBP1

Class: LIG_APCC_ABBA_1

Location: 320:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9996

ASA_SCORE: 80.9167

COIL: 0.8743

CONS_SCORE: 0.3709

DSS_SCORE: 0.4927

HELIX: 0.0903

FCONS_SCORE: 1.2601

RIG_SCORE: 0.7397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E313D	TCGA-A5-A0G2	UCEC	TCGA	LNPFDE	LIG_APCC_ABBA_1	0.1389
p.E313D	DO41235	UCEC	ICGC	LNPFDE	LIG_APCC_ABBA_1	0.1389
p.S335Y	TCGA-AX-A2HC	UCEC	TCGA	LNPFDE	LIG_APCC_ABBA_1	0.5
p.S335Y	DO41572	UCEC	ICGC	LNPFDE	LIG_APCC_ABBA_1	0.5
p.I332M	TCGA-UY-A9PA	BLCA	TCGA	LNPFDE	LIG_APCC_ABBA_1	0.1389
p.I332M	DO219040	BLCA	ICGC	LNPFDE	LIG_APCC_ABBA_1	0.1389
p.Q318H	DO229044	LICA	ICGC	LNPFDE	LIG_APCC_ABBA_1	0.2778
p.A328T	DO23440	LINC	ICGC	LNPFDE	LIG_APCC_ABBA_1	0.25
p.K333N	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LNPFDE	LIG_APCC_ABBA_1	0.2222
p.K333N	ACH-000845	Lung Cancer	CCLE	LNPFDE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDI1	EH domain-binding protein 1	LIG_APCC_ABBA_1	320:325	LNPFDE	APC,CDC20,FZR1	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons