DegronMD

Uniprot ID: Q8NDI1

Source protein: EH domain-binding protein 1

Source gene: EHBP1

Class: DEG_SCF_TRCP1_1

Location: 618:624

E3 ligase: BTRC

DEGRON score: 0.8766

ASA_SCORE: 62.3

COIL: 0.6847

CONS_SCORE: 0.3234

DSS_SCORE: 0.6965

HELIX: 0.1326

FCONS_SCORE: 1.0985

RIG_SCORE: 0.5881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V621A	TCGA-EE-A3J5	SKCM	TCGA	DSGVGES	DEG_SCF_TRCP1_1	0.5825
p.V621A	TCGA-YD-A9TA	SKCM	TCGA	DSGVGES	DEG_SCF_TRCP1_1	0.5825
p.V621A	DO47331	SKCM	ICGC	DSGVGES	DEG_SCF_TRCP1_1	0.5825
p.V621A	DO219503	SKCM	ICGC	DSGVGES	DEG_SCF_TRCP1_1	0.5825
p.G626V	DO219071	HNSC	ICGC	DSGVGES	DEG_SCF_TRCP1_1	0.2778
p.G622V	DO229031	LICA	ICGC	DSGVGES	DEG_SCF_TRCP1_1	0.6421
p.R627M	DO229035	LICA	ICGC	DSGVGES	DEG_SCF_TRCP1_1	0.25
p.G620R	SIDM00789	Colorectal Carcinoma	GDSC	DSGVGES	DEG_SCF_TRCP1_1	0.7568
p.S621C	U031	kidney	COSMIC	DSGVGES	DEG_SCF_TRCP1_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDI1	EH domain-binding protein 1	DEG_SCF_TRCP1_1	618:624	DSGVGES	BTRC	0.8766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons