DegronMD - Q92994(BRF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q298H	TCGA-A2-A0YK	BRCA	TCGA	PPSY	ITCH	291:294	Mutation rewiring degron network	0.2222
p.R513W	TCGA-AA-3713	COAD	TCGA	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0556
p.A493V	TCGA-AP-A1E1	UCEC	TCGA	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1944
p.A493V	TCGA-AX-A1CE	UCEC	TCGA	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1944
p.K502N	TCGA-BR-4370	STAD	TCGA	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation altering degron motif	0.5806
p.Y294C	TCGA-CC-A3M9	LIHC	TCGA	PPSY	ITCH	291:294	Mutation altering degron motif	0.7087
p.P292S	TCGA-D9-A149	SKCM	TCGA	PPSY	ITCH	291:294	Mutation altering degron motif	0.6752
p.P292S	TCGA-FR-A8YC	SKCM	TCGA	PPSY	ITCH	291:294	Mutation altering degron motif	0.6752
p.R302Q	TCGA-FI-A2D5	UCEC	TCGA	PPSY	ITCH	291:294	Mutation rewiring degron network	0.1111
p.E495D	TCGA-VS-A9UH	CESC	TCGA	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.25
p.E291D	DO51642	CESC	ICGC	PPSY	ITCH	291:294	Mutation altering degron motif	0.6758
p.A289V	DO233276	GACA	ICGC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.2778
p.A289V	DO42280	UCEC	ICGC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.2778
p.A289V	DO43226	UCEC	ICGC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.2778
p.K298N	DO38499	STAD	ICGC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.2222
p.Q490K	DO42857	UCEC	ICGC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1111
p.A494T	DO42761	UCEC	ICGC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation blocking ubiquitination signal	0.6667
p.P506T	SIDM00393	Gastric Carcinoma	GDSC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.25
p.P506T	SK-GT-2	stomach	COSMIC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.25
p.A493P	SIDM00210	Ovarian Carcinoma	GDSC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1944
p.A493P	ACH-000657	Ovarian Cancer	CCLE	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1944
p.A493P	A2780	ovary	COSMIC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1944
p.P301S	MDA-MB-436	breast	COSMIC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.1389
p.E285K	SNU-C1	large intestine	COSMIC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.1667
p.S504F	C-33-A	cervix	COSMIC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.3056
p.A289P	A2780	ovary	COSMIC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.2778
p.P302T	SK-GT-2	stomach	COSMIC	PPSY	ITCH	291:294	Mutation rewiring degron network	0.1111
p.G503R	HEC-1	endometrium	COSMIC	LGIYKE	LIG_APCC_ABBA_1	498:503	Mutation altering degron motif	0.7568

Kaplan plot for BRF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRF1

UniProt ID: Q92994

Entrez ID: 2972

Protein name: Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRF1 in