DegronMD

Uniprot ID: Q92994

Source protein: Transcription factor IIIB 90 kDa subunit

Source gene: BRF1

Class: LIG_APCC_ABBA_1

Location: 498:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8922

ASA_SCORE: 115.7667

COIL: 0.8073

CONS_SCORE: 0.3841

DSS_SCORE: 0.4769

HELIX: 0.1648

FCONS_SCORE: 0.9305

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R513W	TCGA-AA-3713	COAD	TCGA	LGIYKE	LIG_APCC_ABBA_1	0.0556
p.A493V	TCGA-AP-A1E1	UCEC	TCGA	LGIYKE	LIG_APCC_ABBA_1	0.1944
p.A493V	TCGA-AX-A1CE	UCEC	TCGA	LGIYKE	LIG_APCC_ABBA_1	0.1944
p.K502N	TCGA-BR-4370	STAD	TCGA	LGIYKE	LIG_APCC_ABBA_1	0.5806
p.E495D	TCGA-VS-A9UH	CESC	TCGA	LGIYKE	LIG_APCC_ABBA_1	0.25
p.Q490K	DO42857	UCEC	ICGC	LGIYKE	LIG_APCC_ABBA_1	0.1111
p.A494T	DO42761	UCEC	ICGC	LGIYKE	LIG_APCC_ABBA_1	0.6667
p.P506T	SIDM00393	Gastric Carcinoma	GDSC	LGIYKE	LIG_APCC_ABBA_1	0.25
p.P506T	SK-GT-2	stomach	COSMIC	LGIYKE	LIG_APCC_ABBA_1	0.25
p.A493P	SIDM00210	Ovarian Carcinoma	GDSC	LGIYKE	LIG_APCC_ABBA_1	0.1944
p.A493P	ACH-000657	Ovarian Cancer	CCLE	LGIYKE	LIG_APCC_ABBA_1	0.1944
p.A493P	A2780	ovary	COSMIC	LGIYKE	LIG_APCC_ABBA_1	0.1944
p.S504F	C-33-A	cervix	COSMIC	LGIYKE	LIG_APCC_ABBA_1	0.3056
p.G503R	HEC-1	endometrium	COSMIC	LGIYKE	LIG_APCC_ABBA_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92994	Transcription factor IIIB 90 kDa subunit	LIG_APCC_ABBA_1	498:503	LGIYKE	APC,CDC20,FZR1	0.8922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons