DegronMD - Q9BZD7(PRRG3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L185Q	TCGA-56-8307	LUSC	TCGA	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.L185Q	DO219139	LUSC	ICGC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.K218N	TCGA-A5-A0G1	UCEC	TCGA	PPKY	ITCH	216:219	Mutation altering degron motif	0.5806
p.K218N	DO42472	UCEC	ICGC	PPKY	ITCH	216:219	Mutation altering degron motif	0.5806
p.S12L	TCGA-AA-A00N	COAD	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.S12L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.S12L	SIDM00534	Colorectal Carcinoma	GDSC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.S12L	ACH-000986	Colon/Colorectal Cancer	CCLE	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.S12L	ACH-001363	Lung Cancer	CCLE	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.S12L	HT-115	large intestine	COSMIC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.S12L	NCI-H2135	lung	COSMIC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1667
p.L5M	TCGA-AX-A2HC	UCEC	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.5999
p.E207K	TCGA-BF-A3DM	SKCM	TCGA	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0833
p.E207K	DO48667	SKCM	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0833
p.P190L	TCGA-C8-A1HG	BRCA	TCGA	PPSY	ITCH	191:194	Mutation rewiring degron network	0.3056
p.P190L	DO1925	BRCA	ICGC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.3056
p.V210M	TCGA-CA-6715	COAD	TCGA	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1667
p.V210M	DO9690	COAD	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1667
p.G228V	TCGA-CV-A45Z	HNSC	TCGA	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0833
p.G228V	DO52064	HNSC	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0833
p.R16Q	TCGA-D3-A3ML	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.R16Q	TCGA-EE-A2A2	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.R16Q	TCGA-ER-A42L	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.R16Q	TCGA-GN-A8LK	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.R16Q	TCGA-WE-A8ZT	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.P217Q	TCGA-EE-A2GT	SKCM	TCGA	PPKY	ITCH	216:219	Mutation altering degron motif	0.7035
p.P217Q	DO37946	SKCM	ICGC	PPKY	ITCH	216:219	Mutation altering degron motif	0.7035
p.A225T	TCGA-EY-A1GK	UCEC	TCGA	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1667
p.A225T	DO42985	UCEC	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1667
p.Q201K	TCGA-KP-A3VZ	UCEC	TCGA	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1389
p.Q201K	DO219777	UCEC	ICGC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1389
p.A229T	TCGA-XK-AAIW	PRAD	TCGA	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0556
p.A229T	DO51407	PRAD	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0556
p.A229T	SIDM01173	Rhabdomyosarcoma	GDSC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.0556
p.A15V	DO228581	GACA	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation substituting flanking lysine	0.1944
p.P215L	DO233253	GACA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.3056
p.E220K	DO233762	GACA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.3056
p.E220K	DO222753	MELA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.3056
p.A2T	DO50970	LICA	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.6028
p.E14V	DO50953	LICA	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1111
p.E14V	DO27813	MALY	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1111
p.L4F	DO230525	LUSC	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.6981
p.S193F	DO222710	MELA	ICGC	PPSY	ITCH	191:194	Mutation altering degron motif	0.6871
p.S9F	DO37659	SKCM	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.25
p.A208V	DO38404	STAD	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1111
p.S213G	DO229259	THCA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.25
p.L13M	DO41572	UCEC	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.S181P	SIDM00570	Gastric Carcinoma	GDSC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.S181P	ACH-000674	Gastric Cancer	CCLE	PPSY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.S181P	NUGC-4	stomach	COSMIC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.S183Y	SIDM00683	Prostate Carcinoma	GDSC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1111
p.S183Y	ACH-000977	lymph node	CCLE	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1111
p.S183Y	LNCaP-Clone-FGC	prostate	COSMIC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1111
p.K218T	SIDM00850	Gastric Carcinoma	GDSC	PPKY	ITCH	216:219	Mutation altering degron motif	0.6195
p.K218T	ACH-000880	Gastric Cancer	CCLE	PPKY	ITCH	216:219	Mutation altering degron motif	0.6195
p.K218T	AGS	stomach	COSMIC	PPKY	ITCH	216:219	Mutation altering degron motif	0.6195
p.A224V	SIDM00160	Biliary Tract Carcinoma	GDSC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1944
p.A224V	ACH-000377	Bile Duct Cancer	CCLE	PPKY	ITCH	216:219	Mutation rewiring degron network	0.1944
p.P200L	ACH-000779	Lung Cancer	CCLE	PPSY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.L8P	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRG3

UniProt ID: Q9BZD7

Entrez ID: 79057

Protein name: Transmembrane gamma-carboxyglutamic acid protein 3 (Proline-rich gamma-carboxyglutamic acid protein 3) (Proline-rich Gla protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRG3 in