DegronMD - Q9BZD7(PRRG3)

GO - Biological processes (BP):

GO - Molecular function (MF): calcium ion binding [GO:0005509]

GO - Cellular component (CC): extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PPSY	ITCH	ITCH,NEDD4	Transmembrane gamma-carboxyglutamic acid protein 3	191:194	More..
PPKY	ITCH	ITCH,NEDD4	Transmembrane gamma-carboxyglutamic acid protein 3	216:219	More..
MAVFLE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Transmembrane gamma-carboxyglutamic acid protein 3	1:6	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P217Q	TCGA-EE-A2GT	SKCM	TCGA	PPKY	ITCH	216:219	Mutation altering degron motif	0.7035
p.P217Q	DO37946	SKCM	ICGC	PPKY	ITCH	216:219	Mutation altering degron motif	0.7035
p.L4F	DO230525	LUSC	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.6981
p.S193F	DO222710	MELA	ICGC	PPSY	ITCH	191:194	Mutation altering degron motif	0.6871
p.K218T	SIDM00850	Gastric Carcinoma	GDSC	PPKY	ITCH	216:219	Mutation altering degron motif	0.6195
p.K218T	ACH-000880	Gastric Cancer	CCLE	PPKY	ITCH	216:219	Mutation altering degron motif	0.6195
p.K218T	AGS	stomach	COSMIC	PPKY	ITCH	216:219	Mutation altering degron motif	0.6195
p.A2T	DO50970	LICA	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.6028
p.L5M	TCGA-AX-A2HC	UCEC	TCGA	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.5999
p.K218N	TCGA-A5-A0G1	UCEC	TCGA	PPKY	ITCH	216:219	Mutation altering degron motif	0.5806
p.K218N	DO42472	UCEC	ICGC	PPKY	ITCH	216:219	Mutation altering degron motif	0.5806
p.P190L	TCGA-C8-A1HG	BRCA	TCGA	PPSY	ITCH	191:194	Mutation rewiring degron network	0.3056
p.P190L	DO1925	BRCA	ICGC	PPSY	ITCH	191:194	Mutation rewiring degron network	0.3056
p.P215L	DO233253	GACA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.3056
p.E220K	DO233762	GACA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.3056
p.E220K	DO222753	MELA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.3056
p.L8P	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.S9F	DO37659	SKCM	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.25
p.S213G	DO229259	THCA	ICGC	PPKY	ITCH	216:219	Mutation rewiring degron network	0.25
p.A15V	DO228581	GACA	ICGC	MAVFLE	LIG_APCC_ABBA_1	1:6	Mutation substituting flanking lysine	0.1944

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Kaplan plot for PRRG3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRG3

UniProt ID: Q9BZD7

Entrez ID: 79057

Protein name: Transmembrane gamma-carboxyglutamic acid protein 3 (Proline-rich gamma-carboxyglutamic acid protein 3) (Proline-rich Gla protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRG3 in