DegronMD

Uniprot ID: Q9BZD7

Source protein: Transmembrane gamma-carboxyglutamic acid protein 3

Source gene: PRRG3

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8575

ASA_SCORE: 89.9833

COIL: 0.7703

CONS_SCORE: 0.9941

DSS_SCORE: 0.5764

HELIX: 0.0197

FCONS_SCORE: 1.0958

RIG_SCORE: 0.8301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S12L	TCGA-AA-A00N	COAD	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.S12L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.S12L	SIDM00534	Colorectal Carcinoma	GDSC	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.S12L	ACH-000986	Colon/Colorectal Cancer	CCLE	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.S12L	ACH-001363	Lung Cancer	CCLE	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.S12L	HT-115	large_intestine	COSMIC	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.S12L	NCI-H2135	lung	COSMIC	MAVFLE	LIG_APCC_ABBA_1	0.1667
p.L5M	TCGA-AX-A2HC	UCEC	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.5999
p.R16Q	TCGA-D3-A3ML	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.0556
p.R16Q	TCGA-EE-A2A2	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.0556
p.R16Q	TCGA-ER-A42L	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.0556
p.R16Q	TCGA-GN-A8LK	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.0556
p.R16Q	TCGA-WE-A8ZT	SKCM	TCGA	MAVFLE	LIG_APCC_ABBA_1	0.0556
p.A15V	DO228581	GACA	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.1944
p.A2T	DO50970	LICA	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.6028
p.E14V	DO50953	LICA	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.1111
p.E14V	DO27813	MALY	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.1111
p.L4F	DO230525	LUSC	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.6981
p.S9F	DO37659	SKCM	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.25
p.L13M	DO41572	UCEC	ICGC	MAVFLE	LIG_APCC_ABBA_1	0.1389
p.L8P	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	MAVFLE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZD7	Transmembrane gamma-carboxyglutamic acid protein 3	LIG_APCC_ABBA_1	1:6	MAVFLE	APC,CDC20,FZR1	0.8575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons