DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPSY
Uniprot ID:
Q8N6L7
Source protein:
Transmembrane protein 252
Source gene:
TMEM252
Class:
ITCH
Location:
144:147
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9986
ASA_SCORE:
56.05
COIL:
0.7815
CONS_SCORE:
0.8531
DSS_SCORE:
0.6515
HELIX:
0.1935
FCONS_SCORE:
1.4895
RIG_SCORE:
0.66
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P144T
TCGA-17-Z045
LUAD
TCGA
PPSY
ITCH
0.7031
p.P145S
SIDM00855
Other Sarcomas
GDSC
PPSY
ITCH
0.6752
p.P145S
ACH-000375
Kidney Cancer
CCLE
PPSY
ITCH
0.6752
p.P145S
G-402
soft_tissue
COSMIC
PPSY
ITCH
0.6752
p.E142K
TCGA-F7-A61V
HNSC
TCGA
PPSY
ITCH
0.2778
p.E142K
DO44437
HNSC
ICGC
PPSY
ITCH
0.2778
p.P141T
DO229045
LICA
ICGC
PPSY
ITCH
0.25
p.G153C
SIDM01261
Breast Carcinoma
GDSC
PPSY
ITCH
0.1667
p.G153C
ACH-002208
Breast Cancer
CCLE
PPSY
ITCH
0.1667
p.G153C
YMB-1-E
breast
COSMIC
PPSY
ITCH
0.1667
p.D138H
SIDM00119
Non-Small Cell Lung Carcinoma
GDSC
PPSY
ITCH
0.1667
p.D138H
ACH-000706
Lung Cancer
CCLE
PPSY
ITCH
0.1667
p.D138H
EKVX
lung
COSMIC
PPSY
ITCH
0.1667
p.G136V
TCGA-XF-AAML
BLCA
TCGA
PPSY
ITCH
0.1111
p.G136V
DO51933
BLCA
ICGC
PPSY
ITCH
0.1111
Showing 1 to 15 of 15 entries
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Drug responses associated with TMEM252 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPSY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z5R6
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
ITCH
587:590
PPSY
ITCH,NEDD4
0.737
More...
Q96KQ4
Apoptosis-stimulating of p53 protein 1
ITCH
459:462
PPSY
ITCH,NEDD4
0.9751
More...
Q8N5I2
Arrestin domain-containing protein 1
ITCH
415:418
PPSY
ITCH,NEDD4
0.9903
More...
Q96B67
Arrestin domain-containing protein 3
ITCH
346:349
PPSY
ITCH,NEDD4
0.77
More...
Q96J65
ATP-binding cassette sub-family C member 12
ITCH
420:423
PPSY
ITCH,NEDD4
0.6228
More...
Q8N2M8
CLK4-associating serine/arginine rich protein
ITCH
286:289
PPSY
ITCH,NEDD4
0.9968
More...
A6NKD9
Coiled-coil domain-containing protein 85C
ITCH
316:319
PPSY
ITCH,NEDD4
0.9875
More...
Q99715
Collagen alpha-1
ITCH
2574:2577
PPSY
ITCH,NEDD4
0.6822
More...
Q96EP5
DAZ-associated protein 1
ITCH
370:373
PPSY
ITCH,NEDD4
0.9278
More...
Q9H7D0
Dedicator of cytokinesis protein 5
ITCH
1438:1441
PPSY
ITCH,NEDD4
0.5355
More...
O94850
Dendrin
ITCH
200:203
PPSY
ITCH,NEDD4
0.8751
More...
O94850
Dendrin
ITCH
230:233
PPSY
ITCH,NEDD4
0.9726
More...
Q9UBP4
Dickkopf-related protein 3
ITCH
91:94
PPSY
ITCH,NEDD4
0.9656
More...
Q9Y5R6
Doublesex- and mab-3-related transcription factor 1
ITCH
296:299
PPSY
ITCH,NEDD4
0.7856
More...
P11161
E3 SUMO-protein ligase EGR2
ITCH
205:208
PPSY
ITCH,NEDD4
0.9358
More...
Q7Z6E9
E3 ubiquitin-protein ligase RBBP6
ITCH
156:159
PPSY
ITCH,NEDD4
0.9269
More...
Q9NT22
EMILIN-3
ITCH
160:163
PPSY
ITCH,NEDD4
0.9466
More...
Q9NRM1
Enamelin
ITCH
853:856
PPSY
ITCH,NEDD4
0.9682
More...
Q14511
Enhancer of filamentation 1
ITCH
109:112
PPSY
ITCH,NEDD4
0.9998
More...
Q6NXG1
Epithelial splicing regulatory protein 1
ITCH
554:557
PPSY
ITCH,NEDD4
0.6605
More...
P19235
Erythropoietin receptor
ITCH
501:504
PPSY
ITCH,NEDD4
0.9994
More...
Q53EP0
Fibronectin type III domain-containing protein 3B
ITCH
110:113
PPSY
ITCH,NEDD4
0.9629
More...
Q5HY92
Fidgetin
ITCH
401:404
PPSY
ITCH,NEDD4
0.9941
More...
Q9BQQ3
Golgi reassembly-stacking protein 1
ITCH
206:209
PPSY
ITCH,NEDD4
0.9258
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
714:717
PPSY
ITCH,NEDD4
0.9896
More...
Showing 1 to 25 of 127 entries
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