DegronMD - Q9UQL6(HDAC5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E401K	TCGA-69-7974	LUAD	TCGA	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7022
p.E401K	DO23850	LUAD	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7022
p.R23W	TCGA-A5-A0G2	UCEC	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.8634
p.R23W	DO41235	UCEC	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.8634
p.S395L	TCGA-BS-A0UV	UCEC	TCGA	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1944
p.S395L	DO42793	UCEC	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1944
p.L18F	TCGA-D3-A2JC	SKCM	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.L18F	DO47578	SKCM	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.G231S	TCGA-D5-5539	COAD	TCGA	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.G231S	DO9506	COAD	ICGC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.D248Y	TCGA-E7-A7DV	BLCA	TCGA	PPSY	ITCH	235:238	Mutation rewiring degron network	0.0556
p.D248Y	DO48583	BLCA	ICGC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.0556
p.P233L	TCGA-EE-A29V	SKCM	TCGA	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2778
p.P233L	DO38006	SKCM	ICGC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2778
p.E19Q	TCGA-EE-A2MS	SKCM	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.2778
p.E19Q	DO37567	SKCM	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.2778
p.L21M	TCGA-G9-6377	PRAD	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.711
p.L21M	DO36348	PRAD	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.711
p.P233T	TCGA-HR-A2OG	SKCM	TCGA	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2778
p.P233T	DO37511	SKCM	ICGC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2778
p.G412S	TCGA-IN-A6RO	STAD	TCGA	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2222
p.G412S	DO51740	STAD	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2222
p.T235M	TCGA-V5-A7RB	ESCA	TCGA	PPSY	ITCH	235:238	Mutation altering degron motif	0.7423
p.R14W	DO50720	ORCA	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.1389
p.S225R	DO229259	THCA	ICGC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.0556
p.A400V	DO229275	THCA	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.6936
p.R409Q	DO229542	UTCA	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.3056
p.P37L	SIDM01943	Colorectal Carcinoma	GDSC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.1111
p.G231R	SIDM00782	Colorectal Carcinoma	GDSC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.G231R	ACH-000381	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.G231R	T84	large intestine	COSMIC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.T32A	SIDM00534	Colorectal Carcinoma	GDSC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.T32A	ACH-000986	Colon/Colorectal Cancer	CCLE	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.T32A	HT-115	large intestine	COSMIC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.G231D	SIDM00150	Colorectal Carcinoma	GDSC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.G231D	ACH-000969	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.G231D	KM12	large intestine	COSMIC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.2222
p.L408V	SIDM01757	Bladder Carcinoma	GDSC	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.6765
p.L408V	ACH-000741	Bladder Cancer	CCLE	ERQALQSLR	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.6765
p.G230R	T84	large intestine	COSMIC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.1944
p.T31A	HT-115	large intestine	COSMIC	PRTSLHSIP	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.2778
p.G230D	KM12	large intestine	COSMIC	PPSY	ITCH	235:238	Mutation rewiring degron network	0.1944

Kaplan plot for HDAC5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HDAC5

UniProt ID: Q9UQL6

Entrez ID: 10014

Protein name: Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HDAC5 in