DegronMD

Uniprot ID: Q9UQL6

Source protein: Histone deacetylase 5

Source gene: HDAC5

Class: DEG_APCC_DBOX_1

Location: 21:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.668

ASA_SCORE: 76.4

COIL: 0.695

CONS_SCORE: 0.3406

DSS_SCORE: 0.4639

HELIX: 0.2288

FCONS_SCORE: 1.013

RIG_SCORE: 0.7108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R23W	TCGA-A5-A0G2	UCEC	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	0.8634
p.R23W	DO41235	UCEC	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	0.8634
p.L18F	TCGA-D3-A2JC	SKCM	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	0.25
p.L18F	DO47578	SKCM	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	0.25
p.E19Q	TCGA-EE-A2MS	SKCM	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	0.2778
p.E19Q	DO37567	SKCM	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	0.2778
p.L21M	TCGA-G9-6377	PRAD	TCGA	PRTSLHSIP	DEG_APCC_DBOX_1	0.711
p.L21M	DO36348	PRAD	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	0.711
p.R14W	DO50720	ORCA	ICGC	PRTSLHSIP	DEG_APCC_DBOX_1	0.1389
p.P37L	SIDM01943	Colorectal Carcinoma	GDSC	PRTSLHSIP	DEG_APCC_DBOX_1	0.1111
p.T32A	SIDM00534	Colorectal Carcinoma	GDSC	PRTSLHSIP	DEG_APCC_DBOX_1	0.25
p.T32A	ACH-000986	Colon/Colorectal Cancer	CCLE	PRTSLHSIP	DEG_APCC_DBOX_1	0.25
p.T32A	HT-115	large_intestine	COSMIC	PRTSLHSIP	DEG_APCC_DBOX_1	0.25
p.T31A	HT-115	large_intestine	COSMIC	PRTSLHSIP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQL6	Histone deacetylase 5	DEG_APCC_DBOX_1	21:29	PRTSLHSIP	APC,CDC20,FZR1	0.668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons