DegronMD

Uniprot ID: Q9UQL6

Source protein: Histone deacetylase 5

Source gene: HDAC5

Class: DEG_APCC_DBOX_1

Location: 400:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5347

ASA_SCORE: 92.9778

COIL: 0.2397

CONS_SCORE: 0.3546

DSS_SCORE: 0.5306

HELIX: 0.7409

FCONS_SCORE: 1.0193

RIG_SCORE: 0.7697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E401K	TCGA-69-7974	LUAD	TCGA	ERQALQSLR	DEG_APCC_DBOX_1	0.7022
p.E401K	DO23850	LUAD	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	0.7022
p.S395L	TCGA-BS-A0UV	UCEC	TCGA	ERQALQSLR	DEG_APCC_DBOX_1	0.1944
p.S395L	DO42793	UCEC	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	0.1944
p.G412S	TCGA-IN-A6RO	STAD	TCGA	ERQALQSLR	DEG_APCC_DBOX_1	0.2222
p.G412S	DO51740	STAD	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	0.2222
p.A400V	DO229275	THCA	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	0.6936
p.R409Q	DO229542	UTCA	ICGC	ERQALQSLR	DEG_APCC_DBOX_1	0.3056
p.L408V	SIDM01757	Bladder Carcinoma	GDSC	ERQALQSLR	DEG_APCC_DBOX_1	0.6765
p.L408V	ACH-000741	Bladder Cancer	CCLE	ERQALQSLR	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQL6	Histone deacetylase 5	DEG_APCC_DBOX_1	400:408	ERQALQSLR	APC,CDC20,FZR1	0.5347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons