DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: ITCH

Location: 156:159

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9269

ASA_SCORE: 57.9

COIL: 0.7968

CONS_SCORE: 0.7011

DSS_SCORE: 0.3603

HELIX: 0.1268

FCONS_SCORE: 1.3511

RIG_SCORE: 0.6743

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T160M	TCGA-F1-A448	STAD	TCGA	PPSY	ITCH	0.3056
p.T160M	DO48044	STAD	ICGC	PPSY	ITCH	0.3056
p.T160M	SIDM01664	Prostate Carcinoma	GDSC	PPSY	ITCH	0.3056
p.T160M	ACH-000952	Prostate Cancer	CCLE	PPSY	ITCH	0.3056
p.P154S	TCGA-18-3409	LUSC	TCGA	PPSY	ITCH	0.2778
p.P154S	DO26444	LUSC	ICGC	PPSY	ITCH	0.2778
p.G153R	TCGA-AN-A0FV	BRCA	TCGA	PPSY	ITCH	0.25
p.G153R	DO5284	BRCA	ICGC	PPSY	ITCH	0.25
p.K166E	TCGA-D5-6530	COAD	TCGA	PPSY	ITCH	0.25
p.K166E	DO8312	COAD	ICGC	PPSY	ITCH	0.25
p.G153C	DO229026	LICA	ICGC	PPSY	ITCH	0.25
p.R163H	TCGA-CN-6995	HNSC	TCGA	PPSY	ITCH	0.2222
p.R163H	DO14854	HNSC	ICGC	PPSY	ITCH	0.2222
p.R163L	DO229037	LICA	ICGC	PPSY	ITCH	0.2222
p.G165C	TCGA-05-4396	LUAD	TCGA	PPSY	ITCH	0.1667
p.G165C	DO229008	LICA	ICGC	PPSY	ITCH	0.1667
p.G165C	DO23838	LUAD	ICGC	PPSY	ITCH	0.1667

Showing 1 to 17 of 17 entries

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Drug responses associated with RBBP6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPSY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5R6	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	ITCH	587:590	PPSY	ITCH,NEDD4	0.737	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	ITCH	459:462	PPSY	ITCH,NEDD4	0.9751	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	415:418	PPSY	ITCH,NEDD4	0.9903	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	346:349	PPSY	ITCH,NEDD4	0.77	More...
Q96J65	ATP-binding cassette sub-family C member 12	ITCH	420:423	PPSY	ITCH,NEDD4	0.6228	More...
Q8N2M8	CLK4-associating serine/arginine rich protein	ITCH	286:289	PPSY	ITCH,NEDD4	0.9968	More...
A6NKD9	Coiled-coil domain-containing protein 85C	ITCH	316:319	PPSY	ITCH,NEDD4	0.9875	More...
Q99715	Collagen alpha-1	ITCH	2574:2577	PPSY	ITCH,NEDD4	0.6822	More...
Q96EP5	DAZ-associated protein 1	ITCH	370:373	PPSY	ITCH,NEDD4	0.9278	More...
Q9H7D0	Dedicator of cytokinesis protein 5	ITCH	1438:1441	PPSY	ITCH,NEDD4	0.5355	More...
O94850	Dendrin	ITCH	200:203	PPSY	ITCH,NEDD4	0.8751	More...
O94850	Dendrin	ITCH	230:233	PPSY	ITCH,NEDD4	0.9726	More...
Q9UBP4	Dickkopf-related protein 3	ITCH	91:94	PPSY	ITCH,NEDD4	0.9656	More...
Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	ITCH	296:299	PPSY	ITCH,NEDD4	0.7856	More...
P11161	E3 SUMO-protein ligase EGR2	ITCH	205:208	PPSY	ITCH,NEDD4	0.9358	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	156:159	PPSY	ITCH,NEDD4	0.9269	More...
Q9NT22	EMILIN-3	ITCH	160:163	PPSY	ITCH,NEDD4	0.9466	More...
Q9NRM1	Enamelin	ITCH	853:856	PPSY	ITCH,NEDD4	0.9682	More...
Q14511	Enhancer of filamentation 1	ITCH	109:112	PPSY	ITCH,NEDD4	0.9998	More...
Q6NXG1	Epithelial splicing regulatory protein 1	ITCH	554:557	PPSY	ITCH,NEDD4	0.6605	More...
P19235	Erythropoietin receptor	ITCH	501:504	PPSY	ITCH,NEDD4	0.9994	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	ITCH	110:113	PPSY	ITCH,NEDD4	0.9629	More...
Q5HY92	Fidgetin	ITCH	401:404	PPSY	ITCH,NEDD4	0.9941	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	ITCH	206:209	PPSY	ITCH,NEDD4	0.9258	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	714:717	PPSY	ITCH,NEDD4	0.9896	More...

Showing 1 to 25 of 127 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSY

Degron related mutations and impact score

Drug responses associated with RBBP6 mutations

All proteins holding degron of PPSY