DegronMD - O75526(RBMXL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G297V	TCGA-05-4390	LUAD	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.G297V	DO23562	LUAD	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.P299Q	TCGA-19-1791	GBM	TCGA	PPSY	ITCH	299:302	Mutation altering degron motif	0.7035
p.P299Q	DO11489	GBM	ICGC	PPSY	ITCH	299:302	Mutation altering degron motif	0.7035
p.R229Q	TCGA-66-2794	LUSC	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.25
p.R229Q	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.25
p.R229Q	DO50311	ESAD	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.25
p.R229Q	DO26683	LUSC	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.25
p.R229Q	DO37406	SKCM	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.25
p.D224E	TCGA-78-8662	LUAD	TCGA	DYR	CBL_MET	224:226	Mutation altering degron motif	0.6758
p.D224E	DO45346	LUAD	ICGC	DYR	CBL_MET	224:226	Mutation altering degron motif	0.6758
p.G236V	TCGA-85-8287	LUSC	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.0556
p.G236V	DO27492	LUSC	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.0556
p.R296W	TCGA-A6-2681	COAD	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.25
p.R296W	TCGA-L5-A891	ESCA	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.25
p.R296W	TCGA-NH-A5IV	COAD	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.25
p.R296W	DO49095	COAD	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.25
p.R296W	DO9788	COAD	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.25
p.R290C	TCGA-AP-A1DV	UCEC	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R290C	DO233269	GACA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R290C	DO233855	GACA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R290C	DO43186	UCEC	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R290C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R290C	ACH-000938	Leukemia	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R290C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0833
p.R307H	TCGA-CM-6171	COAD	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1944
p.R307H	DO8151	COAD	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1944
p.R307H	SIDM00996	Thyroid Gland Carcinoma	GDSC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1944
p.R307H	ACH-001307	Thyroid Cancer	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1944
p.S234L	TCGA-D7-6521	STAD	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1111
p.S234L	DO38747	STAD	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1111
p.P294S	TCGA-DI-A1BU	UCEC	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1944
p.P294S	DO42023	UCEC	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1944
p.P299T	TCGA-DI-A1BU	UCEC	TCGA	PPSY	ITCH	299:302	Mutation altering degron motif	0.7031
p.P299T	DO42023	UCEC	ICGC	PPSY	ITCH	299:302	Mutation altering degron motif	0.7031
p.G297R	TCGA-EB-A299	SKCM	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.G297R	DO37794	SKCM	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.E227K	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	TCGA-IH-A3EA	SKCM	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	DO229359	BTCA	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	DO227994	COCA	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	DO37667	SKCM	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	DO37406	SKCM	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	SIDM00216	Colorectal Carcinoma	GDSC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.E227K	SNU-175	large intestine	COSMIC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.3056
p.S221L	TCGA-G4-6304	COAD	TCGA	DYR	CBL_MET	224:226	Mutation blocking phosphorylation signal	0.6944
p.S221L	DO10639	COAD	ICGC	DYR	CBL_MET	224:226	Mutation blocking phosphorylation signal	0.6944
p.S222R	TCGA-KU-A66S	HNSC	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.2778
p.S222R	DO44456	HNSC	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.2778
p.P299S	TCGA-MT-A51X	HNSC	TCGA	PPSY	ITCH	299:302	Mutation altering degron motif	0.6752
p.P299S	DO44441	HNSC	ICGC	PPSY	ITCH	299:302	Mutation altering degron motif	0.6752
p.E310D	TCGA-NJ-A55R	LUAD	TCGA	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.E310D	DO218947	LUAD	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.A232V	TCGA-VQ-A8P2	STAD	TCGA	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1667
p.A232V	DO51761	STAD	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1667
p.A183V	DO230309	COCA	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.1944
p.P194L	DO50385	ESAD	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation altering degron motif	0.7582
p.R196Q	DO234200	ESAD	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.2778
p.R202H	DO223050	ESCA	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.1111
p.R229W	DO233251	GACA	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.25
p.V184M	DO233882	GACA	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.2222
p.G189S	DO233867	GACA	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation altering degron motif	0.5882
p.G189S	DO38727	STAD	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation altering degron motif	0.5882
p.R202L	DO229028	LICA	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.1111
p.G295V	DO229027	LICA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2222
p.G297E	DO50970	LICA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.G297E	DO229413	PRAD	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.G297E	DO229453	SKCA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.2778
p.E310K	DO222363	MELA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.G303R	DO222562	MELA	ICGC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.3056
p.S215L	DO222843	MELA	ICGC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.0833
p.R202C	DO34680	PACA	ICGC	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.1111
p.R312W	SIDM00938	Breast Carcinoma	GDSC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0556
p.R312W	ACH-000902	Breast Cancer	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.0556
p.A292G	SIDM00680	Colorectal Carcinoma	GDSC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1389
p.A292G	ACH-000957	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1389
p.A292G	LS-180	large intestine	COSMIC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1389
p.Y220F	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	224:226	Mutation blocking phosphorylation signal	0.6667
p.Y220F	ACH-001680	Lymphoma	CCLE	DYR	CBL_MET	224:226	Mutation blocking phosphorylation signal	0.6667
p.Y220F	U-698-M	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	224:226	Mutation blocking phosphorylation signal	0.6667
p.G291S	SIDM01196	Hepatocellular Carcinoma	GDSC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.G291S	ACH-000422	Liver Cancer	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.G291S	SNU-475	liver	COSMIC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1111
p.P194T	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	DGYSGPP	CBL_PTK	188:194	Mutation altering degron motif	0.7031
p.P194T	ACH-000662	Lung Cancer	CCLE	DGYSGPP	CBL_PTK	188:194	Mutation altering degron motif	0.7031
p.F231S	SIDM01229	Neuroblastoma	GDSC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1944
p.F231S	ACH-000312	Neuroblastoma	CCLE	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1944
p.F231S	ACH-002217	Neuroblastoma	CCLE	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1944
p.F231S	BE2-M17	autonomic ganglia	COSMIC	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1944
p.R195P	ACH-000843	Lung Cancer	CCLE	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.3056
p.R196W	ACH-001368	Esophageal Cancer	CCLE	DGYSGPP	CBL_PTK	188:194	Mutation rewiring degron network	0.2778
p.A293T	ACH-001786	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1667
p.P233S	ACH-001959	Bile Duct Cancer	CCLE	DYR	CBL_MET	224:226	Mutation rewiring degron network	0.1389
p.E309K	ACH-002396	Bone Cancer	CCLE	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1389
p.E309K	Sarc9371	bone	COSMIC	PPSY	ITCH	299:302	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBMXL2

UniProt ID: O75526

Entrez ID: 27288

Protein name: RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBMXL2 in