DegronMD

Uniprot ID: O75526

Source protein: RNA-binding motif protein, X-linked-like-2

Source gene: RBMXL2

Class: CBL_PTK

Location: 188:194

E3 ligase: CBL

DEGRON score: 0.9967

ASA_SCORE: 70.1429

COIL: 0.9603

CONS_SCORE: 0.4085

DSS_SCORE: 0.7299

HELIX: 0.0191

FCONS_SCORE: 1.0408

RIG_SCORE: 0.5457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A183V	DO230309	COCA	ICGC	DGYSGPP	CBL_PTK	0.1944
p.P194L	DO50385	ESAD	ICGC	DGYSGPP	CBL_PTK	0.7582
p.R196Q	DO234200	ESAD	ICGC	DGYSGPP	CBL_PTK	0.2778
p.R202H	DO223050	ESCA	ICGC	DGYSGPP	CBL_PTK	0.1111
p.V184M	DO233882	GACA	ICGC	DGYSGPP	CBL_PTK	0.2222
p.G189S	DO233867	GACA	ICGC	DGYSGPP	CBL_PTK	0.5882
p.G189S	DO38727	STAD	ICGC	DGYSGPP	CBL_PTK	0.5882
p.R202L	DO229028	LICA	ICGC	DGYSGPP	CBL_PTK	0.1111
p.R202C	DO34680	PACA	ICGC	DGYSGPP	CBL_PTK	0.1111
p.P194T	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	DGYSGPP	CBL_PTK	0.7031
p.P194T	ACH-000662	Lung Cancer	CCLE	DGYSGPP	CBL_PTK	0.7031
p.R195P	ACH-000843	Lung Cancer	CCLE	DGYSGPP	CBL_PTK	0.3056
p.R196W	ACH-001368	Esophageal Cancer	CCLE	DGYSGPP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75526	RNA-binding motif protein, X-linked-like-2	CBL_PTK	188:194	DGYSGPP	CBL	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons