DegronMD - Q14511(NEDD9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E167K	TCGA-AP-A0LM	UCEC	TCGA	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389
p.E167K	TCGA-BH-A0BT	BRCA	TCGA	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389
p.E167K	DO5618	BRCA	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389
p.E167K	DO43306	UCEC	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389
p.P101S	TCGA-D3-A8GM	SKCM	TCGA	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1111
p.P101S	DO50288	SKCM	ICGC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1111
p.P121L	TCGA-HR-A2OH	SKCM	TCGA	PPSY	ITCH	109:112	Mutation rewiring degron network	0.0833
p.P121L	DO37774	SKCM	ICGC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.0833
p.P148S	TCGA-HU-A4H4	STAD	TCGA	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1667
p.P148S	DO47721	STAD	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1667
p.Q119E	TCGA-P3-A5Q5	HNSC	TCGA	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1389
p.Q119E	DO44450	HNSC	ICGC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1389
p.G116E	TCGA-QH-A870	LGG	TCGA	PPSY	ITCH	109:112	Mutation rewiring degron network	0.2222
p.G116E	DO51838	LGG	ICGC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.2222
p.V158M	DO233652	GACA	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation altering degron motif	0.6097
p.H162N	DO229026	LICA	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.2778
p.Y168N	DO52655	MALY	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation blocking phosphorylation signal	0.5556
p.P169L	DO232863	NACA	ICGC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.0833
p.V120I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1111
p.V120I	ACH-001127	Leukemia	CCLE	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1111
p.V120I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1111
p.F164L	SIDM01611	Endometrial Carcinoma	GDSC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation blocking phosphorylation signal	0.6667
p.Y112F	ACH-000586	Lung Cancer	CCLE	PPSY	ITCH	109:112	Mutation altering degron motif	0.8639
p.Y112F	NCI-H1876	lung	COSMIC	PPSY	ITCH	109:112	Mutation altering degron motif	0.8639
p.S147N	NMC-G1	central nervous system	COSMIC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389
p.G110E	G-MEL	skin	COSMIC	PPSY	ITCH	109:112	Mutation altering degron motif	0.7199
p.G102R	NB14	autonomic ganglia	COSMIC	PPSY	ITCH	109:112	Mutation rewiring degron network	0.1389
p.A167T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VITPVRT	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389
p.G110R	G-MEL	skin	COSMIC	PPSY	ITCH	109:112	Mutation altering degron motif	0.7568
p.A122T	LS-411N	large intestine	COSMIC	PPSY	ITCH	109:112	Mutation blocking phosphorylation signal	0.5

Kaplan plot for NEDD9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEDD9

UniProt ID: Q14511

Entrez ID: 4739

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEDD9 in