DegronMD

Uniprot ID: Q14511

Source protein: Enhancer of filamentation 1

Source gene: NEDD9

Class: DEG_SCF_FBW7_1

Location: 154:160

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 80.1429

COIL: 0.7207

CONS_SCORE: 0.4246

DSS_SCORE: 0.404

HELIX: 0.011

FCONS_SCORE: 1.2517

RIG_SCORE: 0.7673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E167K	TCGA-AP-A0LM	UCEC	TCGA	VITPVRT	DEG_SCF_FBW7_1	0.1389
p.E167K	TCGA-BH-A0BT	BRCA	TCGA	VITPVRT	DEG_SCF_FBW7_1	0.1389
p.E167K	DO5618	BRCA	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.1389
p.E167K	DO43306	UCEC	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.1389
p.P148S	TCGA-HU-A4H4	STAD	TCGA	VITPVRT	DEG_SCF_FBW7_1	0.1667
p.P148S	DO47721	STAD	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.1667
p.V158M	DO233652	GACA	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.6097
p.H162N	DO229026	LICA	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.2778
p.Y168N	DO52655	MALY	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.5556
p.P169L	DO232863	NACA	ICGC	VITPVRT	DEG_SCF_FBW7_1	0.0833
p.F164L	SIDM01611	Endometrial Carcinoma	GDSC	VITPVRT	DEG_SCF_FBW7_1	0.6667
p.S147N	NMC-G1	central_nervous_system	COSMIC	VITPVRT	DEG_SCF_FBW7_1	0.1389
p.A167T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VITPVRT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14511	Enhancer of filamentation 1	DEG_SCF_FBW7_1	154:160	VITPVRT	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons