DegronMD - Q6P6C2(ALKBH5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E293V	TCGA-44-7670	LUAD	TCGA	PPSY	ITCH	303:306	Mutation rewiring degron network	0.0556
p.E293V	DO23555	LUAD	ICGC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.0556
p.E293Q	TCGA-AC-A23H	BRCA	TCGA	PPSY	ITCH	303:306	Mutation rewiring degron network	0.0556
p.E293Q	DO2401	BRCA	ICGC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.0556
p.L302F	TCGA-AQ-A04J	BRCA	TCGA	PPSY	ITCH	303:306	Mutation rewiring degron network	0.3056
p.L302F	DO5312	BRCA	ICGC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.3056
p.P303L	TCGA-CG-5722	STAD	TCGA	PPSY	ITCH	303:306	Mutation altering degron motif	0.7582
p.P303L	DO38244	STAD	ICGC	PPSY	ITCH	303:306	Mutation altering degron motif	0.7582
p.D309V	TCGA-LN-A49S	ESCA	TCGA	PPSY	ITCH	303:306	Mutation rewiring degron network	0.25
p.S22G	DO227987	COCA	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.2222
p.V301L	DO229006	LICA	ICGC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.2778
p.Y26C	DO45346	LUAD	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1111
p.S16T	DO229242	THCA	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.6005
p.R17W	DO41847	UCEC	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.8634
p.R310H	SIDM00993	Plasma Cell Myeloma	GDSC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.2222
p.R310H	ACH-000838	Myeloma	CCLE	PPSY	ITCH	303:306	Mutation rewiring degron network	0.2222
p.R310H	AMO-1	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.2222
p.S296F	SIDM00545	Melanoma	GDSC	PPSY	ITCH	303:306	Mutation blocking phosphorylation signal	0.5833
p.S296F	ACH-000987	Skin Cancer	CCLE	PPSY	ITCH	303:306	Mutation blocking phosphorylation signal	0.5833
p.S296F	Mewo	skin	COSMIC	PPSY	ITCH	303:306	Mutation blocking phosphorylation signal	0.5833
p.S312L	SIDM00846	Cervical Carcinoma	GDSC	PPSY	ITCH	303:306	Mutation blocking phosphorylation signal	0.6111
p.S312L	ACH-001086	Cervical Cancer	CCLE	PPSY	ITCH	303:306	Mutation blocking phosphorylation signal	0.6111
p.S312L	HeLa	cervix	COSMIC	PPSY	ITCH	303:306	Mutation blocking phosphorylation signal	0.6111
p.P303A	SIDM00092	Ovarian Carcinoma	GDSC	PPSY	ITCH	303:306	Mutation altering degron motif	0.7503
p.P303A	ACH-000617	Ovarian Cancer	CCLE	PPSY	ITCH	303:306	Mutation altering degron motif	0.7503
p.P303A	OVCAR-4	ovary	COSMIC	PPSY	ITCH	303:306	Mutation altering degron motif	0.7503
p.R310C	SIDM01619	Endometrial Carcinoma	GDSC	PPSY	ITCH	303:306	Mutation rewiring degron network	0.2222
p.R310C	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	303:306	Mutation rewiring degron network	0.2222
p.A4S	ACH-000427	Gastric Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation substituting flanking lysine	0.2778
p.R16P	ACH-000962	Ovarian Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7512
p.R16P	ACH-001145	Ovarian Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7512
p.R16P	OC-314	ovary	COSMIC	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7512
p.S16P	ACH-000990	Endometrial/Uterine Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.5641
p.R18K	ACH-000990	Endometrial/Uterine Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7237
p.R28H	ACH-000999	Colon/Colorectal Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.0556
p.R28H	SNU-1040	large intestine	COSMIC	LREKLKSMT	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.0556

Kaplan plot for ALKBH5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALKBH5

UniProt ID: Q6P6C2

Entrez ID: 54890

Protein name: RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALKBH5 in