DegronMD

Uniprot ID: Q6P6C2

Source protein: RNA demethylase ALKBH5

Source gene: ALKBH5

Class: DEG_APCC_DBOX_1

Location: 10:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9648

ASA_SCORE: 75.5889

COIL: 0.3049

CONS_SCORE: 0.5764

DSS_SCORE: 0.4276

HELIX: 0.6814

FCONS_SCORE: 1.2284

RIG_SCORE: 0.775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S22G	DO227987	COCA	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	0.2222
p.Y26C	DO45346	LUAD	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	0.1111
p.S16T	DO229242	THCA	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	0.6005
p.R17W	DO41847	UCEC	ICGC	LREKLKSMT	DEG_APCC_DBOX_1	0.8634
p.A4S	ACH-000427	Gastric Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	0.2778
p.R16P	ACH-000962	Ovarian Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	0.7512
p.R16P	ACH-001145	Ovarian Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	0.7512
p.R16P	OC-314	ovary	COSMIC	LREKLKSMT	DEG_APCC_DBOX_1	0.7512
p.S16P	ACH-000990	Endometrial/Uterine Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	0.5641
p.R18K	ACH-000990	Endometrial/Uterine Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	0.7237
p.R28H	ACH-000999	Colon/Colorectal Cancer	CCLE	LREKLKSMT	DEG_APCC_DBOX_1	0.0556
p.R28H	SNU-1040	large_intestine	COSMIC	LREKLKSMT	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P6C2	RNA demethylase ALKBH5	DEG_APCC_DBOX_1	10:18	LREKLKSMT	APC,CDC20,FZR1	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons