DegronMD - P11137(MAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E837Q	TCGA-09-2050	OV	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.1667
p.T845I	TCGA-12-0819	GBM	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.5966
p.D83H	TCGA-27-1830	GBM	TCGA	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.D83H	DO13414	GBM	ICGC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.G74E	TCGA-29-1699	OV	TCGA	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6087
p.G74E	DO32347	OV	ICGC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6087
p.I1636F	TCGA-34-2604	LUSC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.0556
p.R1584I	TCGA-44-2659	LUAD	TCGA	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.0833
p.L812P	TCGA-60-2724	LUSC	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.25
p.S1611L	TCGA-66-2773	LUSC	TCGA	PPSY	ITCH	1606:1609	Mutation blocking phosphorylation signal	0.7222
p.A1585T	TCGA-69-7979	LUAD	TCGA	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.1111
p.D811Y	TCGA-77-A5G1	LUSC	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2222
p.D744N	TCGA-85-A5B5	LUSC	TCGA	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.25
p.D296Y	TCGA-A5-A0G2	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2778
p.K859N	TCGA-AA-3510	COAD	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation substituting flanking lysine	0.2222
p.V1644A	TCGA-AG-3892	READ	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2778
p.A748V	TCGA-AJ-A3BG	UCEC	TCGA	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation altering degron motif	0.5825
p.R293K	TCGA-AP-A0LM	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation altering degron motif	0.6126
p.S285Y	TCGA-AX-A0J0	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation blocking phosphorylation signal	0.6944
p.S285Y	TCGA-BR-8680	STAD	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation blocking phosphorylation signal	0.6944
p.S285Y	TCGA-BS-A0UV	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation blocking phosphorylation signal	0.6944
p.R1648C	TCGA-AX-A1CE	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.719
p.A1655V	TCGA-AZ-4315	COAD	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2778
p.A1655V	TCGA-DF-A2KU	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2778
p.K295Q	TCGA-B5-A0JY	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.3056
p.P1596L	TCGA-BF-AAP7	SKCM	TCGA	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation altering degron motif	0.7582
p.E72D	TCGA-BK-A6W3	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6758
p.E72D	TCGA-EO-A3B0	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6758
p.E72D	DO233095	GACA	ICGC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6758
p.E72D	DO219773	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6758
p.E72D	DO50076	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation altering degron motif	0.6758
p.R844H	TCGA-BR-7717	STAD	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8244
p.R844H	TCGA-QL-A97D	COAD	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8244
p.R844H	SIDM00596	Endometrial Carcinoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8244
p.R844H	HEC-1	endometrium	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8244
p.S1610Y	TCGA-BS-A0UF	UCEC	TCGA	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.3056
p.I1636V	TCGA-CD-5801	STAD	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.0556
p.R1583C	TCGA-CN-5369	HNSC	TCGA	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.0556
p.G1615C	TCGA-D3-A3C8	SKCM	TCGA	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.1667
p.D825G	TCGA-DD-AADQ	LIHC	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2778
p.E60K	TCGA-E2-A10C	BRCA	TCGA	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0556
p.E60K	DO1334	BRCA	ICGC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0556
p.P286H	TCGA-E6-A1LX	UCEC	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2778
p.R1648H	TCGA-EA-A410	CESC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.7133
p.R1648H	TCGA-EO-A22U	UCEC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.7133
p.P760H	TCGA-EB-A24C	SKCM	TCGA	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.1667
p.E837D	TCGA-EO-A22U	UCEC	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.1667
p.P1603S	TCGA-F4-6570	COAD	TCGA	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.2222
p.P1603S	TCGA-F4-6570	COAD	TCGA	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.25
p.R844C	TCGA-F5-6814	READ	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8301
p.R844C	SIDM00680	Colorectal Carcinoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8301
p.R844C	LS-180	large intestine	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.8301
p.S763I	TCGA-FI-A2D5	UCEC	TCGA	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.0833
p.P1657H	TCGA-FS-A1ZZ	SKCM	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2222
p.R1661Q	TCGA-FV-A4ZP	LIHC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1111
p.R1661Q	TCGA-UF-A719	HNSC	TCGA	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1111
p.S833L	TCGA-FW-A3TV	SKCM	TCGA	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation blocking phosphorylation signal	0.5
p.S833L	TCGA-FW-A3TV	SKCM	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5
p.S833L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation blocking phosphorylation signal	0.5
p.S833L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5
p.S833L	ACH-000562	Lung Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation blocking phosphorylation signal	0.5
p.S833L	ACH-000562	Lung Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5
p.S833L	HCC-78	lung	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation blocking phosphorylation signal	0.5
p.S833L	HCC-78	lung	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5
p.W278C	TCGA-G7-6797	KIRP	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.0556
p.S1610F	TCGA-QC-A7B5	SARC	TCGA	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.3056
p.T860M	TCGA-R6-A6XG	ESCA	TCGA	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5278
p.G1589D	TCGA-S9-A6WL	LGG	TCGA	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.2222
p.P286S	TCGA-W3-A825	SKCM	TCGA	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2778
p.D296N	DO48362	BLCA	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2778
p.P287S	DO222693	BTCA	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.3056
p.R1644H	DO49929	CESC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2778
p.R1644H	DO43755	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2778
p.R840H	DO51732	COAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.R840H	DO50337	ESAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.R840H	DO234259	ESAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.R840H	DO38412	STAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.R840H	HEC-1	endometrium	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.P1599S	DO10443	COAD	ICGC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation altering degron motif	0.6752
p.W300C	DO10324	COAD	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1667
p.K855N	DO7783	COAD	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.2222
p.A1651V	DO8842	COAD	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.6936
p.A1651V	DO223286	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.6936
p.K1639T	DO10839	ESAD	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1389
p.D740Y	DO234300	ESAD	ICGC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.1389
p.A825S	DO228712	GACA	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2778
p.A825S	HT-115	large intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2778
p.V836I	DO233253	GACA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.1389
p.G842C	DO233205	GACA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.3056
p.A1641T	DO233825	GACA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1944
p.A744V	DO233935	GACA	ICGC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.25
p.A744V	DO42633	UCEC	ICGC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.25
p.T841I	DO13605	GBM	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.2778
p.R1657Q	DO52105	HNSC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2222
p.R1657Q	DO44911	LIHC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2222
p.G1585D	DO48616	LGG	ICGC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.1111
p.I1642N	DO228925	LICA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation substituting flanking lysine	0.3333
p.Q304H	DO50884	LICA	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.0556
p.D821G	DO52244	LIHC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation altering degron motif	0.7198
p.I1642S	DO23543	LIRI	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation substituting flanking lysine	0.3333
p.T1598S	DO25189	LUAD	ICGC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation altering degron motif	0.7116
p.S1607L	DO26536	LUSC	ICGC	PPSY	ITCH	1606:1609	Mutation altering degron motif	0.7667
p.L808P	DO26540	LUSC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1389
p.D740N	DO50102	LUSC	ICGC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.1389
p.D807Y	DO50096	LUSC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1111
p.P1653L	DO220896	MELA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.7582
p.P845S	DO220903	MELA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.6752
p.V852I	DO220908	MELA	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.3056
p.S829L	DO222810	MELA	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.S829L	DO38159	SKCM	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.S829L	HCC-78	lung	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.E833Q	DO31869	OV	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation blocking phosphorylation signal	0.5
p.E833Q	DO31869	OV	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5
p.T1601N	DO32964	PACA	ICGC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.2778
p.T1601N	DO32964	PACA	ICGC	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.1944
p.V1640A	DO36394	READ	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation blocking phosphorylation signal	0.6111
p.R840C	DO36556	READ	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.R840C	LS-180	large intestine	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.S1606F	DO220239	SARC	ICGC	PPSY	ITCH	1606:1609	Mutation altering degron motif	0.7982
p.P1613L	DO219878	SKCA	ICGC	PPSY	ITCH	1606:1609	Mutation blocking phosphorylation signal	0.6667
p.I1659S	DO229446	SKCA	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1667
p.A825V	DO229459	SKCA	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2778
p.A825V	HT-115	large intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2778
p.P1653H	DO37412	SKCM	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.7694
p.P756H	DO37438	SKCM	ICGC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.2778
p.G1611C	DO47636	SKCM	ICGC	PPSY	ITCH	1606:1609	Mutation blocking phosphorylation signal	0.7222
p.P282S	DO51272	SKCM	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1667
p.P1592L	DO219472	SKCM	ICGC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation blocking phosphorylation signal	0.75
p.S281Y	DO47769	STAD	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1389
p.S281Y	DO41133	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1389
p.S281Y	DO42793	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1389
p.R289K	DO43306	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation altering degron motif	0.7237
p.P282H	DO41020	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1667
p.R1644C	DO42280	UCEC	ICGC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.2778
p.K291Q	DO43041	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation altering degron motif	0.6944
p.D292Y	DO41235	UCEC	ICGC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation altering degron motif	0.7325
p.E833D	DO43755	UCEC	ICGC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation blocking phosphorylation signal	0.5
p.E833D	DO43755	UCEC	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5
p.S1606Y	DO41488	UCEC	ICGC	PPSY	ITCH	1606:1609	Mutation altering degron motif	0.712
p.L860I	DO41488	UCEC	ICGC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation blocking phosphorylation signal	0.5278
p.S759I	DO41331	UCEC	ICGC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.1944
p.D811H	SIDM02030	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.2222
p.N854S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.N854S	ACH-002272	Lymphoma	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.N854S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.25
p.N69D	SIDM00845	Burkitt's Lymphoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.3056
p.H61Q	SIDM00087	Plasma Cell Myeloma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.H61Q	ACH-000817	Myeloma	CCLE	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.H61Q	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.R818I	SIDM00660	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation altering degron motif	0.6991
p.R818I	ACH-000985	Colon/Colorectal Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation altering degron motif	0.6991
p.R818I	LS-411N	large intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation altering degron motif	0.6991
p.A82G	SIDM00057	Neuroblastoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.1111
p.A82G	SIDM00552	Rhabdomyosarcoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.1111
p.A82G	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.1111
p.A82G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.1111
p.A82G	SIDM00560	Gastric Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.1111
p.A82G	SIDM01450	Gastric Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.1111
p.D83Y	SIDM00190	Melanoma	GDSC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.D83Y	ACH-002097	Skin Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.D83Y	CP66-MEL	skin	COSMIC	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.M809T	SIDM01201	Other Blood Cancers	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.M809T	ACH-002289	Leukemia	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.M809T	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.V1638L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1111
p.V1638L	ACH-001363	Lung Cancer	CCLE	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1111
p.V1638L	NCI-H2135	lung	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation rewiring degron network	0.1111
p.P302Q	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1111
p.P302Q	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1111
p.P302Q	ACH-000481	Lung Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1111
p.P302Q	ACH-000892	Lung Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1111
p.P302Q	NCI-H2170	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1111
p.P302Q	NCI-H1563	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1111
p.G846S	SIDM01112	Osteosarcoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.5882
p.G846S	ACH-000748	Bone Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.5882
p.G846S	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.5882
p.G846V	SIDM01112	Osteosarcoma	GDSC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.6421
p.G846V	ACH-000748	Bone Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.6421
p.G846V	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.6421
p.P1603A	SIDM00820	Kidney Carcinoma	GDSC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.2222
p.P1603A	SIDM00820	Kidney Carcinoma	GDSC	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.25
p.P1603A	ACH-002188	Kidney Cancer	CCLE	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.2222
p.P1603A	ACH-002188	Kidney Cancer	CCLE	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.25
p.P1603A	RCC-ER	kidney	COSMIC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.2222
p.P1603A	RCC-ER	kidney	COSMIC	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.25
p.K1587N	SIDM00963	Breast Carcinoma	GDSC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation substituting flanking lysine	0.2778
p.K1587N	ACH-000927	Breast Cancer	CCLE	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation substituting flanking lysine	0.2778
p.K1587N	BT-474	breast	COSMIC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation substituting flanking lysine	0.2778
p.P283L	SIDM00217	Colorectal Carcinoma	GDSC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1944
p.P283L	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1944
p.P283L	SNU-1040	large intestine	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1944
p.A829S	SIDM00534	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.A829S	ACH-000986	Colon/Colorectal Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.A829S	HT-115	large intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.A829V	SIDM00534	Colorectal Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.A829V	SIDM01612	Endometrial Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.A829V	ACH-000986	Colon/Colorectal Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.A829V	HT-115	large intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1667
p.S1608R	SIDM00850	Gastric Carcinoma	GDSC	PPSY	ITCH	1606:1609	Mutation altering degron motif	0.7427
p.S1608R	ACH-000880	Gastric Cancer	CCLE	PPSY	ITCH	1606:1609	Mutation altering degron motif	0.7427
p.S1608R	AGS	stomach	COSMIC	PPSY	ITCH	1606:1609	Mutation altering degron motif	0.7427
p.R816M	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation altering degron motif	0.8632
p.R816M	ACH-002337	Lung Cancer	CCLE	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation altering degron motif	0.8632
p.P807S	SIDM00861	Ovarian Carcinoma	GDSC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1111
p.P807S	ES-2	ovary	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.1111
p.C758F	ACH-001028	Rhabdoid	CCLE	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation rewiring degron network	0.2222
p.R1612H	ACH-001063	Ovarian Cancer	CCLE	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.25
p.D83N	ACH-001390	Breast Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	70:74	Mutation rewiring degron network	0.0833
p.D296V	ACH-001645	Skin Cancer	CCLE	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2778
p.P848S	ACH-001786	Colon/Colorectal Cancer	CCLE	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.5641
p.P1650S	ACH-002396	Bone Cancer	CCLE	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.6752
p.P1650S	Sarc9371	bone	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.6752
p.V282L	NCI-H2135	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.1667
p.K1583N	BT-474	breast	COSMIC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.0556
p.R814I	LS-411N	large intestine	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.3056
p.P279L	SNU-1040	large intestine	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.0833
p.P298Q	NCI-H2170	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2222
p.P298Q	NCI-H1563	lung	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.2222
p.G842S	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.3056
p.M805T	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	TRSRLASVS	DEG_APCC_DBOX_1	815:823	Mutation rewiring degron network	0.0556
p.P294S	Sarc9371	bone	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation altering degron motif	0.6752
p.P1599A	RCC-ER	kidney	COSMIC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation altering degron motif	0.7503
p.P1646S	Sarc9371	bone	COSMIC	IIRTPPKS	DEG_SCF_FBW7_1	1646:1653	Mutation altering degron motif	0.6752
p.P1619L	MCC13	skin	COSMIC	PPSY	ITCH	1606:1609	Mutation blocking phosphorylation signal	0.5
p.N850S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation altering degron motif	0.7069
p.Q764H	SNU-1040	large intestine	COSMIC	PATTPALE	DEG_SCF_FBW7_2	747:754	Mutation substituting flanking lysine	0.1667
p.K288N	BT-474	breast	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation altering degron motif	0.6918
p.P304A	RCC-ER	kidney	COSMIC	PLTPMRE	DEG_SCF_FBW7_2	288:294	Mutation rewiring degron network	0.0556
p.S858G	KATOIII	stomach	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.1389
p.S1604R	AGS	stomach	COSMIC	PTTPGST	DEG_SCF_FBW7_1	1593:1599	Mutation rewiring degron network	0.1944
p.S1604R	AGS	stomach	COSMIC	PPSY	ITCH	1606:1609	Mutation rewiring degron network	0.2778
p.G842V	SJSA-1	bone	COSMIC	SRTGLPPVT	DEG_APCC_DBOX_1	843:851	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP2

UniProt ID: P11137

Entrez ID: 4133

Protein name: Microtubule-associated protein 2 (MAP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP2 in