DegronMD

Uniprot ID: P11137

Source protein: Microtubule-associated protein 2

Source gene: MAP2

Class: DEG_APCC_KENBOX_2

Location: 70:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 90.84

COIL: 0.8626

CONS_SCORE: 0.6143

DSS_SCORE: 0.6049

HELIX: 0.0456

FCONS_SCORE: 1.2772

RIG_SCORE: 0.6743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D83H	TCGA-27-1830	GBM	TCGA	TKENG	DEG_APCC_KENBOX_2	0.0833
p.D83H	DO13414	GBM	ICGC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.G74E	TCGA-29-1699	OV	TCGA	TKENG	DEG_APCC_KENBOX_2	0.6087
p.G74E	DO32347	OV	ICGC	TKENG	DEG_APCC_KENBOX_2	0.6087
p.E72D	TCGA-BK-A6W3	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.6758
p.E72D	TCGA-EO-A3B0	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.6758
p.E72D	DO233095	GACA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.6758
p.E72D	DO219773	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.6758
p.E72D	DO50076	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.6758
p.E60K	TCGA-E2-A10C	BRCA	TCGA	TKENG	DEG_APCC_KENBOX_2	0.0556
p.E60K	DO1334	BRCA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.0556
p.N69D	SIDM00845	Burkitt's Lymphoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.3056
p.H61Q	SIDM00087	Plasma Cell Myeloma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.H61Q	ACH-000817	Myeloma	CCLE	TKENG	DEG_APCC_KENBOX_2	0.0833
p.H61Q	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.A82G	SIDM00057	Neuroblastoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.A82G	SIDM00552	Rhabdomyosarcoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.A82G	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.A82G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.A82G	SIDM00560	Gastric Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.A82G	SIDM01450	Gastric Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.D83Y	SIDM00190	Melanoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.D83Y	ACH-002097	Skin Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	0.0833
p.D83Y	CP66-MEL	skin	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.D83N	ACH-001390	Breast Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_APCC_KENBOX_2	70:74	TKENG	APC,CDC20,FZR1	0.9942	More...
Q08AE8	Protein spire homolog 1	DEG_APCC_KENBOX_2	435:439	TKENG	APC,CDC20,FZR1	0.9955	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_APCC_KENBOX_2	360:364	TKENG	APC,CDC20,FZR1	0.6934	More...
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_APCC_KENBOX_2	807:811	TKENG	APC,CDC20,FZR1	0.9898	More...
Q9HD67	Unconventional myosin-X	DEG_APCC_KENBOX_2	1274:1278	TKENG	APC,CDC20,FZR1	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TKENG

Degron related mutations and impact score

Drug responses associated with MAP2 mutations

All proteins holding degron of TKENG