DegronMD - Q7LBC6(KDM3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1310G	TCGA-AA-A010	COAD	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation altering degron motif	0.6087
p.D1310G	TCGA-AX-A2HC	UCEC	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation altering degron motif	0.6087
p.L1304H	TCGA-AD-6895	COAD	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation altering degron motif	0.7313
p.I354F	TCGA-AN-A04C	BRCA	TCGA	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1667
p.L1296I	TCGA-AP-A059	UCEC	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1111
p.R1294Q	TCGA-AP-A0LM	UCEC	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.0556
p.A1324P	TCGA-CK-4951	COAD	TCGA	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.2778
p.Q370H	TCGA-D1-A15X	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1667
p.K1327N	TCGA-D8-A1JA	BRCA	TCGA	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation blocking ubiquitination signal	0.6389
p.S1322F	TCGA-DA-A960	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation altering degron motif	0.7982
p.N363H	TCGA-EE-A2GO	SKCM	TCGA	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation altering degron motif	0.7423
p.P1314L	TCGA-EE-A3AG	SKCM	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.25
p.P1314L	TCGA-EE-A3AG	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.2222
p.F356S	TCGA-YG-AA3N	SKCM	TCGA	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.2222
p.R1315H	DO5242	BRCA	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.2222
p.R1315H	DO5242	BRCA	ICGC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.25
p.R1315H	DO44442	HNSC	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.2222
p.R1315H	DO44442	HNSC	ICGC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.25
p.S374C	DO44352	CESC	ICGC	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.0556
p.E1295D	DO8898	COAD	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.0833
p.Y1319C	DO20841	KIRP	ICGC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation altering degron motif	0.7087
p.Q1331H	DO44832	LICA	ICGC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation blocking phosphorylation signal	0.5278
p.D1301V	DO23232	LINC	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.25
p.R1315C	DO222557	MELA	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.2222
p.R1315C	DO222557	MELA	ICGC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.25
p.G1323V	DO37742	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.3056
p.V361G	DO47811	STAD	ICGC	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation altering degron motif	0.7532
p.I350V	DO41823	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.0556
p.T1321A	SIDM00455	Pancreatic Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation altering degron motif	0.7139
p.T1321A	ACH-000599	Pancreatic Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation altering degron motif	0.7139
p.T1321A	PA-TU-8902	pancreas	COSMIC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation altering degron motif	0.7139
p.P1316L	SIDM00458	Acute Myeloid Leukemia	GDSC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1944
p.P1316L	SIDM00458	Acute Myeloid Leukemia	GDSC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.2778
p.P1316L	ACH-000751	Leukemia	CCLE	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1944
p.P1316L	ACH-000751	Leukemia	CCLE	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.2778
p.P1316L	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1944
p.P1316L	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1318:1322	Mutation rewiring degron network	0.2778
p.H1298Y	SIDM00608	Plasma Cell Myeloma	GDSC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1667
p.H1298Y	ACH-000714	Myeloma	CCLE	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1667
p.H1298Y	KMS-11	haematopoietic and lymphoid tissue	COSMIC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.1667
p.G1300V	SIDM00094	Kidney Carcinoma	GDSC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.2222
p.G1300V	ACH-002199	Kidney Cancer	CCLE	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.2222
p.G1300V	SN12C	kidney	COSMIC	LPQTPLDT	DEG_SCF_FBW7_1	1304:1311	Mutation rewiring degron network	0.2222
p.R355C	SIDM01619	Endometrial Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1944
p.R355C	ACH-000984	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1944
p.R352C	ACH-001518	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	360:364	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM3B

UniProt ID: Q7LBC6

Entrez ID: 51780

Protein name: Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM3B in