DegronMD

Uniprot ID: Q7LBC6

Source protein: Lysine-specific demethylase 3B

Source gene: KDM3B

Class: DEG_SCF_FBW7_1

Location: 1304:1311

E3 ligase: FBXW7

DEGRON score: 0.9686

ASA_SCORE: 82.275

COIL: 0.8656

CONS_SCORE: 0.4709

DSS_SCORE: 0.5611

HELIX: 0.0573

FCONS_SCORE: 0.929

RIG_SCORE: 0.6695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1310G	TCGA-AA-A010	COAD	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	0.6087
p.D1310G	TCGA-AX-A2HC	UCEC	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	0.6087
p.L1304H	TCGA-AD-6895	COAD	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	0.7313
p.L1296I	TCGA-AP-A059	UCEC	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	0.1111
p.R1294Q	TCGA-AP-A0LM	UCEC	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	0.0556
p.P1314L	TCGA-EE-A3AG	SKCM	TCGA	LPQTPLDT	DEG_SCF_FBW7_1	0.25
p.R1315H	DO5242	BRCA	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	0.2222
p.R1315H	DO44442	HNSC	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	0.2222
p.E1295D	DO8898	COAD	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	0.0833
p.D1301V	DO23232	LINC	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	0.25
p.R1315C	DO222557	MELA	ICGC	LPQTPLDT	DEG_SCF_FBW7_1	0.2222
p.P1316L	SIDM00458	Acute Myeloid Leukemia	GDSC	LPQTPLDT	DEG_SCF_FBW7_1	0.1944
p.P1316L	ACH-000751	Leukemia	CCLE	LPQTPLDT	DEG_SCF_FBW7_1	0.1944
p.P1316L	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	LPQTPLDT	DEG_SCF_FBW7_1	0.1944
p.H1298Y	SIDM00608	Plasma Cell Myeloma	GDSC	LPQTPLDT	DEG_SCF_FBW7_1	0.1667
p.H1298Y	ACH-000714	Myeloma	CCLE	LPQTPLDT	DEG_SCF_FBW7_1	0.1667
p.H1298Y	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	LPQTPLDT	DEG_SCF_FBW7_1	0.1667
p.G1300V	SIDM00094	Kidney Carcinoma	GDSC	LPQTPLDT	DEG_SCF_FBW7_1	0.2222
p.G1300V	ACH-002199	Kidney Cancer	CCLE	LPQTPLDT	DEG_SCF_FBW7_1	0.2222
p.G1300V	SN12C	kidney	COSMIC	LPQTPLDT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7LBC6	Lysine-specific demethylase 3B	DEG_SCF_FBW7_1	1304:1311	LPQTPLDT	FBXW7	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons