DegronMD

Uniprot ID: Q7LBC6

Source protein: Lysine-specific demethylase 3B

Source gene: KDM3B

Class: DEG_APCC_KENBOX_2

Location: 360:364

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6934

ASA_SCORE: 102.96

COIL: 0.8336

CONS_SCORE: 0.4197

DSS_SCORE: 0.4424

HELIX: 0.0938

FCONS_SCORE: 0.9966

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I354F	TCGA-AN-A04C	BRCA	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1667
p.Q370H	TCGA-D1-A15X	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1667
p.N363H	TCGA-EE-A2GO	SKCM	TCGA	TKENG	DEG_APCC_KENBOX_2	0.7423
p.F356S	TCGA-YG-AA3N	SKCM	TCGA	TKENG	DEG_APCC_KENBOX_2	0.2222
p.S374C	DO44352	CESC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.0556
p.V361G	DO47811	STAD	ICGC	TKENG	DEG_APCC_KENBOX_2	0.7532
p.I350V	DO41823	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.0556
p.R355C	SIDM01619	Endometrial Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.1944
p.R355C	ACH-000984	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	0.1944
p.R352C	ACH-001518	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_APCC_KENBOX_2	70:74	TKENG	APC,CDC20,FZR1	0.9942	More...
Q08AE8	Protein spire homolog 1	DEG_APCC_KENBOX_2	435:439	TKENG	APC,CDC20,FZR1	0.9955	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_APCC_KENBOX_2	360:364	TKENG	APC,CDC20,FZR1	0.6934	More...
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_APCC_KENBOX_2	807:811	TKENG	APC,CDC20,FZR1	0.9898	More...
Q9HD67	Unconventional myosin-X	DEG_APCC_KENBOX_2	1274:1278	TKENG	APC,CDC20,FZR1	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons