DegronMD - Q08AE8(SPIRE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P353Q	TCGA-09-2044	OV	TCGA	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.5924
p.P353Q	DO28923	OV	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.5924
p.L421F	TCGA-62-A46O	LUAD	TCGA	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.L421F	DO26240	LUAD	ICGC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.L421F	SIDM00193	Colorectal Carcinoma	GDSC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.L421F	ACH-000991	Colon/Colorectal Cancer	CCLE	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.L421F	SNU-81	large intestine	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.G430S	TCGA-66-2758	LUSC	TCGA	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.G430S	DO26731	LUSC	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.Q444H	TCGA-AJ-A5DW	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.Q444H	DO50075	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.L421I	TCGA-AP-A1DV	UCEC	TCGA	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.L421I	DO43186	UCEC	ICGC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.K419N	TCGA-AP-A1E0	UCEC	TCGA	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.3056
p.K419N	DO43154	UCEC	ICGC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.3056
p.R365Q	TCGA-AR-A250	BRCA	TCGA	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation rewiring degron network	0.0556
p.R365Q	DO1802	BRCA	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation rewiring degron network	0.0556
p.F407L	TCGA-B5-A11N	UCEC	TCGA	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.1944
p.F407L	DO41458	UCEC	ICGC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.1944
p.P353S	TCGA-BS-A0UV	UCEC	TCGA	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.5641
p.P353S	DO42793	UCEC	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.5641
p.M426V	TCGA-BT-A2LA	BLCA	TCGA	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.0833
p.M426V	TCGA-BT-A2LA	BLCA	TCGA	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.1111
p.M426V	DO561	BLCA	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.0833
p.M426V	DO561	BLCA	ICGC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.1111
p.G430C	TCGA-D3-A2JC	SKCM	TCGA	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.G430C	DO47578	SKCM	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.K239N	TCGA-DD-AAE7	LIHC	TCGA	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.2778
p.K239N	DO52262	LIHC	ICGC	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.2778
p.A241V	TCGA-E6-A1LX	UCEC	TCGA	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation altering degron motif	0.5825
p.A241V	DO41020	UCEC	ICGC	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation altering degron motif	0.5825
p.P505S	TCGA-FI-A2D5	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.6752
p.P505S	DO41331	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.6752
p.S495P	TCGA-FI-A2D5	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0556
p.S495P	DO41331	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0556
p.Q249K	TCGA-ND-A4WC	UCS	TCGA	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.2222
p.T509I	TCGA-QC-A7B5	SARC	TCGA	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.8189
p.T509I	TCGA-QC-A7B5	SARC	TCGA	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.8189
p.T509I	DO220239	SARC	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.8189
p.T509I	DO220239	SARC	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.8189
p.T509S	TCGA-QC-A7B5	SARC	TCGA	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.8227
p.T509S	TCGA-QC-A7B5	SARC	TCGA	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7116
p.T509S	DO220239	SARC	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.8227
p.T509S	DO220239	SARC	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7116
p.Q445K	DO225357	BRCA	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1667
p.P361T	DO228948	LICA	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation rewiring degron network	0.1667
p.Y405C	DO228850	LICA	ICGC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.1389
p.P517T	DO229034	LICA	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.2222
p.P517T	DO229034	LICA	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1111
p.T362N	DO229036	LICA	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation blocking phosphorylation signal	0.5833
p.P505H	DO229036	LICA	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7694
p.N448K	DO229009	LICA	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.0833
p.K360I	DO23524	LIRI	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation substituting flanking lysine	0.3056
p.P447L	DO27907	ORCA	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1111
p.N438S	DO232761	PBCA	ICGC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation altering degron motif	0.7069
p.P517S	DO229229	THCA	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.2222
p.P517S	DO229229	THCA	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1111
p.P500S	DO229232	THCA	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.1667
p.P500S	DO229232	THCA	ICGC	PISST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1944
p.P350L	SIDM00086	Kidney Carcinoma	GDSC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.6471
p.P350L	ACH-002195	Kidney Cancer	CCLE	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.6471
p.P350L	RXF393	kidney	COSMIC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation altering degron motif	0.6471
p.Q434R	SIDM00394	Cervical Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.3056
p.Q434R	ACH-001650	Cervical Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.3056
p.Q434R	SISO	cervix	COSMIC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.3056
p.P510S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.6752
p.D255G	SIDM00537	Colorectal Carcinoma	GDSC	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.0556
p.D255G	ACH-000982	Colon/Colorectal Cancer	CCLE	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.0556
p.D255G	ACH-001345	Colon/Colorectal Cancer	CCLE	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.0556
p.D255G	GP5d	large intestine	COSMIC	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.0556
p.K246N	SIDM00920	Breast Carcinoma	GDSC	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.3056
p.K246N	ACH-000783	Breast Cancer	CCLE	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.3056
p.K246N	CAMA-1	breast	COSMIC	AKENL	DEG_APCC_KENBOX_2	241:245	Mutation rewiring degron network	0.3056
p.V427A	ACH-000978	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1111
p.V427A	ACH-000978	Endometrial/Uterine Cancer	CCLE	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.0833
p.V427A	EN	endometrium	COSMIC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1111
p.V427A	EN	endometrium	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.0833
p.P415R	ACH-001677	Lymphoma	CCLE	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation altering degron motif	0.7512
p.E420K	L-428	haematopoietic and lymphoid tissue	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.2778
p.Q420R	SISO	cervix	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.2778
p.P421L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.25
p.P498L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	ISSTPQPE	DEG_SCF_FBW7_2	506:513	Mutation substituting flanking lysine	0.2222
p.P498L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PISST	DEG_SPOP_SBC_1	505:509	Mutation substituting flanking lysine	0.25
p.L407F	SNU-81	large intestine	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.1944
p.V413A	EN	endometrium	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation altering degron motif	0.6936
p.Y444C	L-540	haematopoietic and lymphoid tissue	COSMIC	TKENG	DEG_APCC_KENBOX_2	435:439	Mutation rewiring degron network	0.1944
p.E343K	L-428	haematopoietic and lymphoid tissue	COSMIC	SRPPLNPVS	DEG_APCC_DBOX_1	347:355	Mutation rewiring degron network	0.2222
p.R410H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VTTPEST	DEG_SCF_FBW7_1	412:418	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPIRE1

UniProt ID: Q08AE8

Entrez ID: 56907

Protein name: Protein spire homolog 1 (Spir-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPIRE1 in