DegronMD

Uniprot ID: Q08AE8

Source protein: Protein spire homolog 1

Source gene: SPIRE1

Class: DEG_SPOP_SBC_1

Location: 505:509

E3 ligase: SPOP

DEGRON score: 0.9941

ASA_SCORE: 84.8

COIL: 0.94

CONS_SCORE: 0.3835

DSS_SCORE: 0.81

HELIX: 0.0294

FCONS_SCORE: 1.0335

RIG_SCORE: 0.6129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P505S	TCGA-FI-A2D5	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	0.6752
p.P505S	DO41331	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	0.6752
p.S495P	TCGA-FI-A2D5	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	0.0556
p.S495P	DO41331	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T509I	TCGA-QC-A7B5	SARC	TCGA	PISST	DEG_SPOP_SBC_1	0.8189
p.T509I	DO220239	SARC	ICGC	PISST	DEG_SPOP_SBC_1	0.8189
p.T509S	TCGA-QC-A7B5	SARC	TCGA	PISST	DEG_SPOP_SBC_1	0.7116
p.T509S	DO220239	SARC	ICGC	PISST	DEG_SPOP_SBC_1	0.7116
p.P517T	DO229034	LICA	ICGC	PISST	DEG_SPOP_SBC_1	0.1111
p.P505H	DO229036	LICA	ICGC	PISST	DEG_SPOP_SBC_1	0.7694
p.P517S	DO229229	THCA	ICGC	PISST	DEG_SPOP_SBC_1	0.1111
p.P500S	DO229232	THCA	ICGC	PISST	DEG_SPOP_SBC_1	0.1944
p.P498L	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PISST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons